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Hcrtr1 Gene Detail
Summary
  • Symbol
    Hcrtr1
  • Name
    hypocretin (orexin) receptor 1
  • Synonyms
    OX1R
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385650
    NCBI Gene: 230777
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130024010-130033152 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385650
 protein coding gene Chr4:130024010-130033389 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028844
 protein coding gene Chr4:132116998-132126085 (-)
A/J MGP_AJ_G0028803
 protein coding gene Chr4:126819773-126828967 (-)
AKR/J MGP_AKRJ_G0028756
 protein coding gene Chr4:130371138-130380376 (-)
BALB/cJ MGP_BALBcJ_G0028826
 protein coding gene Chr4:127432237-127441379 (-)
C3H/HeJ MGP_C3HHeJ_G0028540
 protein coding gene Chr4:130425307-130434449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029268
 protein coding gene Chr4:137071148-137080334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026540
 protein coding gene Chr4:119942739-119951852 (-)
CAST/EiJ MGP_CASTEiJ_G0027972
 protein coding gene Chr4:128635372-128644422 (-)
CBA/J MGP_CBAJ_G0028506
 protein coding gene Chr4:140547124-140556318 (-)
DBA/2J MGP_DBA2J_G0028655
 protein coding gene Chr4:127255118-127264360 (-)
FVB/NJ MGP_FVBNJ_G0028622
 protein coding gene Chr4:126042080-126050731 (-)
LP/J MGP_LPJ_G0028756
 protein coding gene Chr4:132444187-132453346 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028648
 protein coding gene Chr4:145258042-145267182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029306
 protein coding gene Chr4:130736569-130745763 (-)
PWK/PhJ MGP_PWKPhJ_G0027694
 protein coding gene Chr4:123872113-123881951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027520
 protein coding gene Chr4:126617641-126626683 (-)
WSB/EiJ MGP_WSBEiJ_G0028053
 protein coding gene Chr4:130884622-130893757 (-)



Homology
more
  • Human Ortholog
    HCRTR1, hypocretin receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCRTR1, hypocretin receptor 1
  • Synonyms
    ORXR1, OX1R, OXR1
  • Links
    NCBI Gene ID: 3061
    neXtProt AC: NX_O43613
    UniProt: O43613

  • Chr Location
    1p35.2; chr1:31617686-31634492 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display increased susceptibility to pharmacologically induced seizures. Mice homozygous for a second null allele display a decrease in depression like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    53
  • cDNA Data
    6
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028778 Ensembl Gene Model | MGI Sequence Detail 9143 C57BL/6J ±  kb
transcript ENSMUST00000119423 Ensembl | MGI Sequence Detail 2439 Not Applicable  
polypeptide ENSMUSP00000112630 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 6
    Primer pair 3
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 75
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:46166 Sakurai T, et al., Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85
  • Latest
    J:345716 Tsuneoka Y, et al., Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction. eNeuro. 2024 Feb;11(2):ENEURO.0474-23.2024
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory