Ablim2 MGI Mouse Gene Detail - MGI:2385758 - actin-binding LIM protein 2

Symbol

Ablim2
Name

actin-binding LIM protein 2

Feature Type

protein coding gene
IDs

MGI:2385758
NCBI Gene: 231148
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:35915224-36042317 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 18.75 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

3934 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385758	protein coding gene	Chr5:35915200-36042323 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029484	protein coding gene	Chr5:34058142-34195874 (+)
A/J	MGP_AJ_G0029451	protein coding gene	Chr5:32945760-33073928 (+)
AKR/J	MGP_AKRJ_G0029400	protein coding gene	Chr5:34207226-34334382 (+)
BALB/cJ	MGP_BALBcJ_G0029461	protein coding gene	Chr5:33458438-33587533 (+)
C3H/HeJ	MGP_C3HHeJ_G0029183	protein coding gene	Chr5:34216820-34346459 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029915	protein coding gene	Chr5:35966203-36096225 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027152	protein coding gene	Chr5:30703959-30828052 (+)
CAST/EiJ	MGP_CASTEiJ_G0028592	protein coding gene	Chr5:33315695-33446163 (+)
CBA/J	MGP_CBAJ_G0029151	protein coding gene	Chr5:36810513-36945491 (+)
DBA/2J	MGP_DBA2J_G0029299	protein coding gene	Chr5:33090671-33217787 (+)
FVB/NJ	MGP_FVBNJ_G0029258	protein coding gene	Chr5:32559313-32687948 (+)
LP/J	MGP_LPJ_G0029384	protein coding gene	Chr5:34481864-34612320 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029288	protein coding gene	Chr5:37599635-37725952 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029948	protein coding gene	Chr5:33702804-33829133 (+)
PWK/PhJ	MGP_PWKPhJ_G0028317	protein coding gene	Chr5:32254912-32386308 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028148	protein coding gene	Chr5:33171748-33302976 (+)
WSB/EiJ	MGP_WSBEiJ_G0028673	protein coding gene	Chr5:33764358-33894438 (+)

Human Ortholog

ABLIM2, actin binding LIM protein family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABLIM2, actin binding LIM protein family member 2
Links

HGNC:19195

NCBI Gene ID: 84448

neXtProt AC: NX_Q6H8Q1

UniProt: Q6H8Q1
Chr Location

4p16.1; chr4:7965310-8158832 (-) GRCh38

MGI Vertebrate Homology

Ablim2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABLIM2
Gene Tree

Ablim2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

16
Radiation induced

4
Spontaneous

1
Targeted

3
Genomic Mutations

8 involving Ablim2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

71 strains or lines available

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

23
cDNA Data

32
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ABLIM2

Xenbase ablim2

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All Sequences

177
RefSeq

99
UniProt

13
CCDS

CCDS19235.1, CCDS51473.1, CCDS51474.1, CCDS51475.1, CCDS51476.1, CCDS51477.1

Ensembl

ENSMUSG00000029095 (Evidence)
NCBI Gene

231148

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029095	Ensembl Gene Model \| MGI Sequence Detail	127094	C57BL/6J	± kb
transcript	ENSMUST00000129347	Ensembl \| MGI Sequence Detail	1995	Not Applicable
polypeptide	ENSMUSP00000123525	Ensembl \| MGI Sequence Detail	664	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000003585 actin-binding LIM protein 2

(term hierarchy)
InterPro Domains

IPR051618 Actin-binding LIM

IPR032402 Putative adherens-junction anchoring domain

IPR003128 Villin headpiece

IPR036886 Villin headpiece domain superfamily

IPR001781 Zinc finger, LIM-type
GlyGen

Q8BL65 7 sites, 1 O-linked glycan (7 sites)

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All nucleic 36

Genomic 2

cDNA 32

Primer pair 2

Microarray probesets 4

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MGI:2140943

Summaries

All 56

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 31
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ablim2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45958	Chr5:35915219-35915290 (+)	31 bp
Tssr45959	Chr5:35915295-35915310 (+)	79 bp
Tssr45960	Chr5:35943495-35943522 (+)	28,285 bp
Tssr45961	Chr5:35971700-35971715 (+)	56,484 bp
Tssr45962	Chr5:35971719-35971744 (+)	56,508 bp
Tssr45963	Chr5:35971768-35971797 (+)	56,559 bp
Tssr45964	Chr5:35971799-35971826 (+)	56,589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24