Mical1 MGI Mouse Gene Detail - MGI:2385847 - microtubule associated monooxygenase, calponin and LIM domain containing 1

Symbol

Mical1
Name

microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms

MGC:27831, MGC:38321, Nical

Feature Type

protein coding gene
IDs

MGI:2385847
NCBI Gene: 171580
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:41352310-41363028 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.41 cM
Mapping Data

1 experiment

SNPs within 2kb

315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385847	protein coding gene	Chr10:41351693-41363028 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017173	protein coding gene	Chr10:40118208-40128922 (+)
A/J	MGP_AJ_G0017150	protein coding gene	Chr10:39000661-39011379 (+)
AKR/J	MGP_AKRJ_G0017110	protein coding gene	Chr10:39586037-39596755 (+)
BALB/cJ	MGP_BALBcJ_G0017112	protein coding gene	Chr10:39069621-39080339 (+)
C3H/HeJ	MGP_C3HHeJ_G0016933	protein coding gene	Chr10:39901555-39912276 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017571	protein coding gene	Chr10:41341261-41352086 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015267	protein coding gene	Chr10:36938394-36949291 (+)
CAST/EiJ	MGP_CASTEiJ_G0016512	protein coding gene	Chr10:40102857-40113722 (+)
CBA/J	MGP_CBAJ_G0016907	protein coding gene	Chr10:43226398-43237116 (+)
DBA/2J	MGP_DBA2J_G0017012	protein coding gene	Chr10:38504709-38515427 (+)
FVB/NJ	MGP_FVBNJ_G0017007	protein coding gene	Chr10:38004268-38014986 (+)
LP/J	MGP_LPJ_G0017089	protein coding gene	Chr10:40106241-40116955 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017037	protein coding gene	Chr10:44050131-44060849 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017608	protein coding gene	Chr10:39567193-39577911 (+)
PWK/PhJ	MGP_PWKPhJ_G0016292	protein coding gene	Chr10:38381086-38392058 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016076	protein coding gene	Chr10:39382938-39393701 (+)
WSB/EiJ	MGP_WSBEiJ_G0016575	protein coding gene	Chr10:39892724-39903473 (+)

Human Ortholog

MICAL1, microtubule associated monooxygenase, calponin and LIM domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MICAL1, microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms

MICAL, MICAL-1, NICAL
Links

HGNC:20619

NCBI Gene ID: 64780

neXtProt AC: NX_Q8TDZ2

UniProt: Q8TDZ2
Chr Location

6q21; chr6:109444062-109465968 (-) GRCh38

MGI Vertebrate Homology

Mical1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MICAL1
Gene Tree

Mical1

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Mical1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO leads to increased mortality after cardiac stress. Mice show impaired lamina-specific targeting of mossy fibre axons onto CA3 pyramidal neurons in the developing hippocampus.

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All GO Annotations

43
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

60
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

103
RefSeq

24
UniProt

3
CCDS

CCDS35888.1, CCDS48547.1

Ensembl

ENSMUSG00000019823 (Evidence)
NCBI Gene

171580

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019823	Ensembl Gene Model \| MGI Sequence Detail	10719	C57BL/6J	± kb
transcript	ENSMUST00000019967	Ensembl \| MGI Sequence Detail	3563	Not Applicable
polypeptide	ENSMUSP00000019967	Ensembl \| MGI Sequence Detail	1048	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010399 [F-actin]-monooxygenase MICAL1

(term hierarchy)
PDB

2BRA, 2BRY, 2C4C, 4TXI, 4TXK
EC

1.14.13.225, 1.6.3.1
InterPro Domains

IPR022735 bMERB domain

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR050540 F-actin Monooxygenase Mical

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR001781 Zinc finger, LIM-type

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All nucleic 60

cDNA 60

Microarray probesets 4

Summaries

All 50

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:336712 Niu F, et al., F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov;6(45)

TSS for Mical1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93045	Chr10:41352322-41352388 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24