Nomo1 MGI Mouse Gene Detail - MGI:2385850

Symbol

Nomo1
Name

nodal modulator 1
Synonyms

D7Ertd156e, MGC:37454, MGC:37848, Nomo, PM5

Feature Type

protein coding gene
IDs

MGI:2385850
NCBI Gene: 211548
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:45683122-45733636 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.66 cM
Mapping Data

2 experiments

SNPs within 2kb

2087 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385850	protein coding gene	Chr7:45683120-45733636 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032258	protein coding gene	Chr7:46373526-46429153 (+)
A/J	MGP_AJ_G0032237	protein coding gene	Chr7:45435390-45487168 (+)
AKR/J	MGP_AKRJ_G0032173	protein coding gene	Chr7:46721030-46774457 (+)
BALB/cJ	MGP_BALBcJ_G0032249	protein coding gene	Chr7:45437064-45487492 (+)
C3H/HeJ	MGP_C3HHeJ_G0031964	protein coding gene	Chr7:47212990-47267841 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032741	protein coding gene	Chr7:48653233-48706893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029755	protein coding gene	Chr7:47982310-48033756 (+)
CAST/EiJ	MGP_CASTEiJ_G0031292	protein coding gene	Chr7:38645757-38708521 (+)
CBA/J	MGP_CBAJ_G0031929	protein coding gene	Chr7:50278200-50333812 (+)
DBA/2J	MGP_DBA2J_G0032086	protein coding gene	Chr7:45116518-45171766 (+)
FVB/NJ	MGP_FVBNJ_G0032038	protein coding gene	Chr7:44901396-44956715 (+)
LP/J	MGP_LPJ_G0032165	protein coding gene	Chr7:47084480-47135726 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032075	protein coding gene	Chr7:48926340-48985150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032756	protein coding gene	Chr7:45925561-45980547 (+)
PWK/PhJ	MGP_PWKPhJ_G0031015	protein coding gene	Chr7:38488769-38542443 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030853	protein coding gene	Chr7:33942851-34015057 (+)
WSB/EiJ	MGP_WSBEiJ_G0031410	protein coding gene	Chr7:46422086-46475232 (+)

Human Ortholog

NOMO1, NODAL modulator 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOMO1, NODAL modulator 1
Synonyms

Nomo, PM5
Links

HGNC:30060

NCBI Gene ID: 23420

neXtProt AC: NX_Q15155

UniProt: P69849, Q15155
Chr Location

16p13.11; chr16:14833721-14896157 (+) GRCh38

Human Ortholog

NOMO2, NODAL modulator 2
Synonyms

Nomo, PM5
Links

HGNC:22652

NCBI Gene ID: 283820

neXtProt AC: NX_Q5JPE7

UniProt: Q5JPE7
Chr Location

16p12.3; chr16:18417325-18562211 (-) GRCh38

Human Ortholog

NOMO3, NODAL modulator 3
Synonyms

Nomo
Links

HGNC:25242

NCBI Gene ID: 408050

neXtProt AC: NX_P69849

UniProt: P69849
Chr Location

16p13.11; chr16:16232506-16300806 (+) GRCh38

MGI Vertebrate Homology

Nomo1 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOMO1, NOMO2, NOMO3
Gene Tree

Nomo1

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

36
cDNA Data

149
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

82
RefSeq

2
UniProt

1
CCDS

CCDS21273.1

Ensembl

ENSMUSG00000030835 (Evidence)
NCBI Gene

211548

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030835	Ensembl Gene Model \| MGI Sequence Detail	50515	C57BL/6J	± kb
transcript	ENSMUST00000033121	Ensembl \| MGI Sequence Detail	4257	Not Applicable
polypeptide	ENSMUSP00000033121	Ensembl \| MGI Sequence Detail	1214	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000033366 rodent-type BOS complex subunit NOMO1

(term hierarchy)
InterPro Domains

IPR013784 Carbohydrate-binding-like fold

IPR008969 Carboxypeptidase-like, regulatory domain superfamily

IPR051417 Serine-Aspartate Repeat-Containing
GlyGen

Q6GQT9 6 sites, 8 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 152

cDNA 150

Primer pair 2

Microarray probesets 4

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MGI:1098832

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:327863 Perez-Garcia J, et al., Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration. Cancers (Basel). 2022 Aug 20;14(16)

TSS for Nomo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66668	Chr7:45683141-45683247 (+)	72 bp
Tssr66669	Chr7:45683250-45683270 (+)	138 bp
Tssr66670	Chr7:45700082-45700085 (+)	16,962 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24