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Nudt18 Gene Detail
Summary
  • Symbol
    Nudt18
  • Name
    nudix hydrolase 18
  • Synonyms
    MGC:38179, nudix (nucleoside diphosphate linked moiety X)-type motif 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385853
    NCBI Gene: 213484
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70815264-70820128 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385853
 protein coding gene Chr14:70815077-70820128 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021544
 protein coding gene Chr14:65235860-65240581 (+)
A/J MGP_AJ_G0021503
 protein coding gene Chr14:63847070-63851793 (+)
AKR/J MGP_AKRJ_G0021479
 protein coding gene Chr14:65759874-65764598 (+)
BALB/cJ MGP_BALBcJ_G0021509
 protein coding gene Chr14:63610064-63614787 (+)
C3H/HeJ MGP_C3HHeJ_G0021286
 protein coding gene Chr14:65474864-65479588 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021948
 protein coding gene Chr14:68146916-68151640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019488
 protein coding gene Chr14:61683804-61688520 (+)
CAST/EiJ MGP_CASTEiJ_G0020803
 protein coding gene Chr14:62072684-62077405 (+)
CBA/J MGP_CBAJ_G0021253
 protein coding gene Chr14:70293734-70298458 (+)
DBA/2J MGP_DBA2J_G0021376
 protein coding gene Chr14:63231670-63236394 (+)
FVB/NJ MGP_FVBNJ_G0021355
 protein coding gene Chr14:62661043-62665749 (+)
LP/J MGP_LPJ_G0021447
 protein coding gene Chr14:66475518-66480241 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021384
 protein coding gene Chr14:69174447-69179171 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021972
 protein coding gene Chr14:65022104-65026828 (+)
PWK/PhJ MGP_PWKPhJ_G0020547
 protein coding gene Chr14:60000941-60005670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020380
 protein coding gene Chr14:60951105-60955726 (+)
WSB/EiJ MGP_WSBEiJ_G0020856
 protein coding gene Chr14:65336006-65340732 (+)



Homology
more
  • Human Ortholog
    NUDT18, nudix hydrolase 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUDT18, nudix hydrolase 18
  • Synonyms
    MTH3
  • Links
    NCBI Gene ID: 79873
    neXtProt AC: NX_Q6ZVK8
    UniProt: Q6ZVK8

  • Chr Location
    8p21.3; chr8:22106874-22110482 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nudt18
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    12
  • cDNA Data
    44
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 213484 NCBI Gene Model | MGI Sequence Detail 4865 C57BL/6J ±  kb
transcript NM_001360474 RefSeq | MGI Sequence Detail 3978 C57BL/6  
polypeptide Q3U2V3 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory