Cpne5 MGI Mouse Gene Detail - MGI:2385908

Symbol

Cpne5
Name

copine V
Synonyms

A830083G22Rik, MGC:47475

Feature Type

protein coding gene
IDs

MGI:2385908
NCBI Gene: 240058
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:29375495-29456764 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.14 cM
Mapping Data

1 experiment

SNPs within 2kb

1008 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385908	protein coding gene	Chr17:29374530-29457141 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023459	protein coding gene	Chr17:28662780-28752235 (-)
A/J	MGP_AJ_G0023417	protein coding gene	Chr17:27667502-27748041 (-)
AKR/J	MGP_AKRJ_G0023382	protein coding gene	Chr17:27907776-27996368 (-)
BALB/cJ	MGP_BALBcJ_G0023422	protein coding gene	Chr17:27951195-28032055 (-)
C3H/HeJ	MGP_C3HHeJ_G0023183	protein coding gene	Chr17:28297886-28381975 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023864	protein coding gene	Chr17:29806427-29897720 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021339	protein coding gene	Chr17:25012384-25094110 (-)
CAST/EiJ	MGP_CASTEiJ_G0022684	protein coding gene	Chr17:28261986-28360567 (-)
CBA/J	MGP_CBAJ_G0023158	protein coding gene	Chr17:30917408-31005226 (-)
DBA/2J	MGP_DBA2J_G0023288	protein coding gene	Chr17:27214953-27295274 (-)
FVB/NJ	MGP_FVBNJ_G0023258	protein coding gene	Chr17:27039264-27127801 (-)
LP/J	MGP_LPJ_G0023366	protein coding gene	Chr17:28918466-29004112 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023276	protein coding gene	Chr17:30263195-30352128 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023906	protein coding gene	Chr17:28367206-28456046 (-)
PWK/PhJ	MGP_PWKPhJ_G0022434	protein coding gene	Chr17:26033852-26132764 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022252	protein coding gene	Chr17:26355080-26438670 (-)
WSB/EiJ	MGP_WSBEiJ_G0022746	protein coding gene	Chr17:28329830-28413364 (-)

Human Ortholog

CPNE5, copine 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPNE5, copine 5
Synonyms

COPN5, CPN5
Links

HGNC:2318

NCBI Gene ID: 57699

neXtProt AC: NX_Q9HCH3

UniProt: Q9HCH3
Chr Location

6p21.2

MGI Vertebrate Homology

Cpne5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CPNE5
Gene Tree

Cpne5

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Endonuclease-mediated

2
Gene trapped

44
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal growth, brain structure, locomotor activity and memory, but show a decreased anxiety-related response in the elevated plus maze and elevated platform task.

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All GO Annotations

11
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

62
cDNA Data

19
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpne9

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All Sequences

50
RefSeq

12
UniProt

3
CCDS

CCDS28592.1

Ensembl

ENSMUSG00000024008 (Evidence)
NCBI Gene

240058

			Length	Strain/Species	Flank
genomic	240058	NCBI Gene Model \| MGI Sequence Detail	81270	C57BL/6J	± kb
transcript	NM_001360239	RefSeq \| MGI Sequence Detail	4417	C57BL/6
polypeptide	Q8JZW4	UniProt \| EBI \| MGI Sequence Detail	593	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005820 copine-5

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR045052 Copine

IPR037768 Copine, C2B domain

IPR010734 Copine, C-terminal

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 3

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MGI:2444312

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 13
Earliest

J:86882 Creutz CE, et al., The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. J Biol Chem. 1998 Jan 16;273(3):1393-402
Latest

J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602

TSS for Cpne5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147191	Chr17:29457180-29457226 (-)	-439 bp
Tssr147190	Chr17:29457063-29457140 (-)	-338 bp
Tssr147189	Chr17:29457044-29457057 (-)	-287 bp
Tssr147188	Chr17:29456750-29456801 (-)	-12 bp
Tssr147187	Chr17:29408084-29408096 (-)	48,674 bp
Tssr147186	Chr17:29408065-29408081 (-)	48,691 bp
Tssr147185	Chr17:29386416-29386435 (-)	70,338 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24