C1qtnf5 MGI Mouse Gene Detail - MGI:2385958 - C1q and tumor necrosis factor related protein 5

Symbol

C1qtnf5
Name

C1q and tumor necrosis factor related protein 5
Synonyms

CTRP5

Feature Type

protein coding gene
IDs

MGI:2385958
NCBI Gene: 235312
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:44018542-44020484 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.62 cM
Mapping Data

2 experiments

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385958	protein coding gene	Chr9:44013067-44020484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034692	protein coding gene	Chr9:42561180-42563122 (+)
A/J	MGP_AJ_G0034672	protein coding gene	Chr9:41392877-41394819 (+)
AKR/J	MGP_AKRJ_G0034598	protein coding gene	Chr9:42250063-42252005 (+)
BALB/cJ	MGP_BALBcJ_G0034663	protein coding gene	Chr9:41132883-41134825 (+)
C3H/HeJ	MGP_C3HHeJ_G0034374	protein coding gene	Chr9:42703772-42705714 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035185	protein coding gene	Chr9:43839580-43841522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032099	protein coding gene	Chr9:40983578-40985515 (+)
CAST/EiJ	MGP_CASTEiJ_G0033697	protein coding gene	Chr9:42545580-42547522 (+)
CBA/J	MGP_CBAJ_G0034347	protein coding gene	Chr9:45417570-45419512 (+)
DBA/2J	MGP_DBA2J_G0034506	protein coding gene	Chr9:41305946-41307888 (+)
FVB/NJ	MGP_FVBNJ_G0034446	protein coding gene	Chr9:40555091-40557033 (+)
LP/J	MGP_LPJ_G0034587	protein coding gene	Chr9:42864258-42866200 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034490	protein coding gene	Chr9:47295545-47297487 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035205	protein coding gene	Chr9:42144672-42146614 (+)
PWK/PhJ	MGP_PWKPhJ_G0033402	protein coding gene	Chr9:41172090-41174034 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033237	protein coding gene	Chr9:42445020-42446961 (+)
WSB/EiJ	MGP_WSBEiJ_G0033810	protein coding gene	Chr9:42182326-42184268 (+)

Human Ortholog

C1QTNF5, C1q and TNF related 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF5, C1q and TNF related 5
Synonyms

CTRP5, MFRP
Links

HGNC:14344

NCBI Gene ID: 114902

neXtProt AC: NX_Q9BXJ0

UniProt: Q9BXJ0
Chr Location

11q23.3; chr11:119338942-119346705 (-) GRCh38

MGI Vertebrate Homology

C1qtnf5 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QTNF5
Gene Tree

C1qtnf5

Diseases

1 with C1qtnf5 mouse models; 1 with human C1QTNF5 associations

Human Disease

Mouse Models

late-onset retinal degeneration

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

33 phenotypes from 4 alleles in 4 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

1
Targeted

7
Incidental Mutations

CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Heterozygotes for a knock-in mutation show features of late-onset retinal degeneration, whereas hetero- or homozygotes for the same knock-in generated by a different group lack retinal defects. Homozygous null mice exhibit reduced hepatic steatosis and improved insulin action on a high-fat diet.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

48
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase c1qtnf5

ZFIN c1qtnf5

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All Sequences

57
RefSeq

10
UniProt

1
CCDS

CCDS52777.1

Ensembl

ENSMUSG00000079592 (Evidence)
NCBI Gene

235312

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079592	Ensembl Gene Model \| MGI Sequence Detail	1943	C57BL/6J	± kb
transcript	ENSMUST00000114816	Ensembl \| MGI Sequence Detail	1259	Not Applicable
polypeptide	ENSMUSP00000110464	Ensembl \| MGI Sequence Detail	243	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004887 complement C1q tumor necrosis factor-related protein 5

(term hierarchy)

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 3

Diseases 2

Gene Ontology 9

Phenotypes 19
Earliest

J:78123 Kameya S, et al., Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet. 2002 Aug 1;11(16):1879-86
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C1qtnf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84619	Chr9:44018523-44018532 (+)	-14 bp
Tssr84620	Chr9:44018565-44018576 (+)	29 bp
Tssr84621	Chr9:44018583-44018652 (+)	76 bp
Tssr84622	Chr9:44018969-44019015 (+)	450 bp
Tssr84623	Chr9:44019040-44019058 (+)	507 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24