Cerk MGI Mouse Gene Detail - MGI:2386052

Symbol

Cerk
Name

ceramide kinase
Synonyms

D330016D08Rik, mKIAA1646

Feature Type

protein coding gene
IDs

MGI:2386052
NCBI Gene: 223753
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr15:86023329-86070342 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.52 cM
Mapping Data

2 experiments

SNPs within 2kb

1493 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2386052	protein coding gene	Chr15:86023302-86070537 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022202	protein coding gene	Chr15:87092352-87145332 (-)
A/J	MGP_AJ_G0022161	protein coding gene	Chr15:83820683-83870661 (-)
AKR/J	MGP_AKRJ_G0022136	protein coding gene	Chr15:86292009-86343174 (-)
BALB/cJ	MGP_BALBcJ_G0022167	protein coding gene	Chr15:83945683-83997333 (-)
C3H/HeJ	MGP_C3HHeJ_G0021937	protein coding gene	Chr15:86240718-86297327 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022612	protein coding gene	Chr15:90318956-90378130 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020137	protein coding gene	Chr15:80129207-80171844 (-)
CAST/EiJ	MGP_CASTEiJ_G0021459	protein coding gene	Chr15:87063995-87121364 (-)
CBA/J	MGP_CBAJ_G0021904	protein coding gene	Chr15:93364376-93429566 (-)
DBA/2J	MGP_DBA2J_G0022031	protein coding gene	Chr15:83276616-83325129 (-)
FVB/NJ	MGP_FVBNJ_G0022010	protein coding gene	Chr15:82360886-82412059 (-)
LP/J	MGP_LPJ_G0022102	protein coding gene	Chr15:87237713-87292670 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022030	protein coding gene	Chr15:97992905-98044259 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022627	protein coding gene	Chr15:86318167-86370141 (-)
PWK/PhJ	MGP_PWKPhJ_G0021200	protein coding gene	Chr15:83300080-83349886 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021034	protein coding gene	Chr15:86023087-86073733 (-)
WSB/EiJ	MGP_WSBEiJ_G0021508	protein coding gene	Chr15:86798122-86849619 (-)

Human Ortholog

CERK, ceramide kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CERK, ceramide kinase
Synonyms

dA59H18.2, dA59H18.3, hCERK, LK4
Links

HGNC:19256

NCBI Gene ID: 64781

neXtProt AC: NX_Q8TCT0

UniProt: Q8TCT0
Chr Location

22q13.31; chr22:46684410-46738252 (-) GRCh38

MGI Vertebrate Homology

Cerk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CERK
Gene Tree

Cerk

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Cerk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

914
Tissues

175
cDNA Data

11
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cerk

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All Sequences

70
RefSeq

18
UniProt

3
CCDS

CCDS27728.1

Ensembl

ENSMUSG00000035891 (Evidence)
NCBI Gene

223753

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035891	Ensembl Gene Model \| MGI Sequence Detail	47014	C57BL/6J	± kb
transcript	ENSMUST00000044332	Ensembl \| MGI Sequence Detail	4518	Not Applicable
polypeptide	ENSMUSP00000038203	Ensembl \| MGI Sequence Detail	531	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005363 ceramide kinase

(term hierarchy)
EC

2.7.1.138
InterPro Domains

IPR045363 Ceramide kinase, C-terminal domain

IPR001206 Diacylglycerol kinase, catalytic domain

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR050187 Lipid Phosphate Formation and Regulation

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 4

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MGI:2146081, MGI:2443499

Summaries

All 72

Developmental Gene Expression 9

Diseases 1

Gene Ontology 9

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:349405 Dong W, et al., Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2. Exp Mol Med. 2024 Apr;56(4):946-958

TSS for Cerk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135795	Chr15:86071120-86071127 (-)	-782 bp
Tssr135794	Chr15:86070514-86070555 (-)	-193 bp
Tssr135793	Chr15:86070337-86070386 (-)	-20 bp
Tssr135792	Chr15:86070233-86070258 (-)	96 bp
Tssr135791	Chr15:86070203-86070228 (-)	126 bp
Tssr135790	Chr15:86070063-86070138 (-)	241 bp
Tssr135789	Chr15:86069880-86069967 (-)	418 bp
Tssr135788	Chr15:86069861-86069872 (-)	475 bp
Tssr135787	Chr15:86054030-86054043 (-)	16,305 bp
Tssr135786	Chr15:86052446-86052470 (-)	17,884 bp
Tssr135785	Chr15:86044727-86044743 (-)	25,607 bp
Tssr135784	Chr15:86044627-86044638 (-)	25,709 bp
Tssr135783	Chr15:86034766-86034771 (-)	35,573 bp
Tssr135782	Chr15:86025549-86025587 (-)	44,774 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24