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Pars2 Gene Detail
Summary
  • Symbol
    Pars2
  • Name
    prolyl-tRNA synthetase (mitochondrial)(putative)
  • Synonyms
    MGC:47008
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386296
    NCBI Gene: 230577
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:106508266-106512479 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 49.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386296
 protein coding gene Chr4:106508266-106512479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028523
 protein coding gene Chr4:107288440-107292653 (+)
A/J MGP_AJ_G0028486
 protein coding gene Chr4:103456223-103460436 (+)
AKR/J MGP_AKRJ_G0028433
 protein coding gene Chr4:105969584-105973797 (+)
BALB/cJ MGP_BALBcJ_G0028505
 protein coding gene Chr4:103644124-103648337 (+)
C3H/HeJ MGP_C3HHeJ_G0028219
 protein coding gene Chr4:106723291-106727504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028945
 protein coding gene Chr4:111160347-111164560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026236
 protein coding gene Chr4:98733102-98737275 (+)
CAST/EiJ MGP_CASTEiJ_G0027655
 protein coding gene Chr4:104523281-104527471 (+)
CBA/J MGP_CBAJ_G0028188
 protein coding gene Chr4:114747602-114751815 (+)
DBA/2J MGP_DBA2J_G0028336
 protein coding gene Chr4:103073201-103077414 (+)
FVB/NJ MGP_FVBNJ_G0028304
 protein coding gene Chr4:101928949-101933162 (+)
LP/J MGP_LPJ_G0028437
 protein coding gene Chr4:107488621-107492834 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028330
 protein coding gene Chr4:120071872-120076085 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028981
 protein coding gene Chr4:106218578-106222791 (+)
PWK/PhJ MGP_PWKPhJ_G0027381
 protein coding gene Chr4:101308929-101313142 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027205
 protein coding gene Chr4:103599538-103603733 (+)
WSB/EiJ MGP_WSBEiJ_G0027736
 protein coding gene Chr4:106390204-106394417 (+)



Homology
more
  • Human Ortholog
    PARS2, prolyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARS2, prolyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    DEE75, EIEE75, MT-PRORS, proRS
  • Links
    NCBI Gene ID: 25973
    neXtProt AC: NX_Q7L3T8
    UniProt: Q7L3T8

  • Chr Location
    1p32.3; chr1:54756898-54764523 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    29
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Pars2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    52 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 230577 NCBI Gene Model | MGI Sequence Detail 4214 C57BL/6J ±  kb
transcript NM_001285783 RefSeq | MGI Sequence Detail 3094 C57BL/6  
polypeptide Q8CFI5 UniProt | EBI | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030280 probable proline--tRNA ligase, mitochondrial
    (term hierarchy)
  • EC
    6.1.1.15
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    IPR004154 Anticodon-binding
    IPR036621 Anticodon-binding domain superfamily
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR033730 Prokaryote proline-tRNA ligase core domain
    IPR044140 Proline--tRNA ligase, anticodon binding domain
    IPR002316 Proline-tRNA ligase, class IIa
    IPR050062 Proline-tRNA synthetase
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory