Abca8a MGI Mouse Gene Detail - MGI:2386846 - ATP-binding cassette, sub-family A member 8a

Symbol

Abca8a
Name

ATP-binding cassette, sub-family A member 8a

Feature Type

protein coding gene
IDs

MGI:2386846
NCBI Gene: 217258
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:109916460-109986804 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 73.07 cM
Mapping Data

1 experiment

SNPs within 2kb

2327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2386846	protein coding gene	Chr11:109916460-109988403 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019341	protein coding gene	Chr11:113623312-113702285 (-)
A/J	MGP_AJ_G0019309	protein coding gene	Chr11:108716120-108787536 (-)
AKR/J	MGP_AKRJ_G0019278	protein coding gene	Chr11:111973280-112042961 (-)
BALB/cJ	MGP_BALBcJ_G0019283	protein coding gene	Chr11:109131402-109207019 (-)
C3H/HeJ	MGP_C3HHeJ_G0019092	protein coding gene	Chr11:112253584-112336623 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019733	protein coding gene	Chr11:117042857-117126306 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017356	protein coding gene	Chr11:105900602-105973744 (-)
CAST/EiJ	MGP_CASTEiJ_G0018645	protein coding gene	Chr11:113415338-113494425 (-)
CBA/J	MGP_CBAJ_G0019061	protein coding gene	Chr11:121882412-121964401 (-)
DBA/2J	MGP_DBA2J_G0019173	protein coding gene	Chr11:108176783-108265204 (-)
FVB/NJ	MGP_FVBNJ_G0019164	protein coding gene	Chr11:107653753-107724116 (-)
LP/J	MGP_LPJ_G0019243	protein coding gene	Chr11:114027864-114109012 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019195	protein coding gene	Chr11:121007697-121093836 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019770	protein coding gene	Chr11:112532048-112605590 (-)
PWK/PhJ	MGP_PWKPhJ_G0018410	protein coding gene	Chr11:109344125-109417971 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018202	protein coding gene	Chr11:112332961-112409975 (-)
WSB/EiJ	MGP_WSBEiJ_G0018697	protein coding gene	Chr11:112461967-112540437 (-)

Human Ortholog

ABCA8, ATP binding cassette subfamily A member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCA8, ATP binding cassette subfamily A member 8
Links

HGNC:38

NCBI Gene ID: 10351

neXtProt AC: NX_O94911

UniProt: O94911
Chr Location

17q24.2; chr17:68867289-68955392 (-) GRCh38

MGI Vertebrate Homology

Abca8a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCA8
Gene Tree

Abca8a

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

103 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

110
cDNA Data

21
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

58
RefSeq

14
UniProt

6
CCDS

CCDS48974.1

Ensembl

ENSMUSG00000041828 (Evidence)
NCBI Gene

217258

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041828	Ensembl Gene Model \| MGI Sequence Detail	70345	C57BL/6J	± kb
transcript	ENSMUST00000100287	Ensembl \| MGI Sequence Detail	5619	Not Applicable
polypeptide	ENSMUSP00000097860	Ensembl \| MGI Sequence Detail	1620	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004535 ABC-type organic anion transporter ABCA8A

(term hierarchy)
EC

7.6.2.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR013525 ABC-2 type transporter, transmembrane domain

IPR026082 ABC transporter A

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q8K442 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 2

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 6
Earliest

J:73769 Nakamura K, et al., Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family. Biochim Biophys Acta. 2001 Nov 11;1522(1):53-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abca8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111593	Chr11:109988370-109988412 (-)	-1,587 bp
Tssr111592	Chr11:109986800-109986869 (-)	-31 bp
Tssr111591	Chr11:109986781-109986795 (-)	16 bp
Tssr111590	Chr11:109969946-109969963 (-)	16,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24