Dusp7 MGI Mouse Gene Detail - MGI:2387100 - dual specificity phosphatase 7

Symbol

Dusp7
Name

dual specificity phosphatase 7
Synonyms

MKP-X, PYST2

Feature Type

protein coding gene
IDs

MGI:2387100
NCBI Gene: 235584
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:106245831-106252923 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.46 cM
Mapping Data

1 experiment

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387100	protein coding gene	Chr9:106245831-106252923 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035227	protein coding gene	Chr9:108167483-108175973 (+)
A/J	MGP_AJ_G0035207	protein coding gene	Chr9:104264474-104272190 (+)
AKR/J	MGP_AKRJ_G0035139	protein coding gene	Chr9:106860226-106867797 (+)
BALB/cJ	MGP_BALBcJ_G0035200	protein coding gene	Chr9:103948590-103956484 (+)
C3H/HeJ	MGP_C3HHeJ_G0034910	protein coding gene	Chr9:107269792-107279550 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035720	protein coding gene	Chr9:111141830-111159525 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032618	protein coding gene	Chr9:101755549-101762755 (+)
CAST/EiJ	MGP_CASTEiJ_G0034222	protein coding gene	Chr9:107168750-107177993 (+)
CBA/J	MGP_CBAJ_G0034879	protein coding gene	Chr9:115058692-115068043 (+)
DBA/2J	MGP_DBA2J_G0035040	protein coding gene	Chr9:103724008-103730838 (+)
FVB/NJ	MGP_FVBNJ_G0034988	protein coding gene	Chr9:102502614-102510794 (+)
LP/J	MGP_LPJ_G0035116	protein coding gene	Chr9:108388183-108395954 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035027	protein coding gene	Chr9:116682769-116692261 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035742	protein coding gene	Chr9:107104300-107110067 (+)
PWK/PhJ	MGP_PWKPhJ_G0033929	protein coding gene	Chr9:104019468-104026666 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033764	protein coding gene	Chr9:107168582-107175579 (+)
WSB/EiJ	MGP_WSBEiJ_G0034342	protein coding gene	Chr9:107005427-107014436 (+)

Human Ortholog

DUSP7, dual specificity phosphatase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP7, dual specificity phosphatase 7
Synonyms

MKPX, PYST2
Links

HGNC:3073

NCBI Gene ID: 1849

neXtProt AC: NX_Q16829

UniProt: Q16829
Chr Location

3p21.2; chr3:52048919-52056571 (-) GRCh38

MGI Vertebrate Homology

Dusp7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP7
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp7

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null mice exhibit prenatal lethality.

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All GO Annotations

28
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

112
cDNA Data

61
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp7

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS23475.2

Ensembl

ENSMUSG00000053716 (Evidence)
NCBI Gene

235584

			Length	Strain/Species	Flank
genomic	235584	NCBI Gene Model \| MGI Sequence Detail	7093	C57BL/6J	± kb
transcript	NM_153459	RefSeq \| MGI Sequence Detail	3227	C57BL/6
polypeptide	Q91Z46	UniProt \| EBI \| MGI Sequence Detail	422	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006757 dual specificity protein phosphatase 7

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 62

cDNA 61

Primer pair 1

Microarray probesets 3

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MGI:2143192

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;

TSS for Dusp7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86884	Chr9:106245142-106245175 (+)	-672 bp
Tssr86885	Chr9:106245750-106245771 (+)	-70 bp
Tssr86886	Chr9:106245793-106245839 (+)	-15 bp
Tssr86887	Chr9:106248022-106248054 (+)	2,207 bp
Tssr86888	Chr9:106249282-106249304 (+)	3,462 bp
Tssr86889	Chr9:106251406-106251418 (+)	5,581 bp
Tssr86890	Chr9:106251503-106251543 (+)	5,692 bp
Tssr86891	Chr9:106251624-106251628 (+)	5,795 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24