Dusp9 MGI Mouse Gene Detail - MGI:2387107 - dual specificity phosphatase 9

Symbol

Dusp9
Name

dual specificity phosphatase 9
Synonyms

Mpk4, Pyst3

Feature Type

protein coding gene
IDs

MGI:2387107
NCBI Gene: 75590
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

ChrX:72683025-72687120 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.37 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387107	protein coding gene	ChrX:72682995-72687120 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035813	protein coding gene	ChrX:69406388-69410489 (+)
A/J	MGP_AJ_G0035794	protein coding gene	ChrX:69607081-69611176 (+)
AKR/J	MGP_AKRJ_G0035719	protein coding gene	ChrX:71415004-71419099 (+)
BALB/cJ	MGP_BALBcJ_G0035779	protein coding gene	ChrX:68640134-68644229 (+)
C3H/HeJ	MGP_C3HHeJ_G0035484	protein coding gene	ChrX:69877988-69882083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036309	protein coding gene	ChrX:71539177-71543272 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033153	protein coding gene	ChrX:68644401-68648465 (+)
CAST/EiJ	MGP_CASTEiJ_G0034775	protein coding gene	ChrX:55226760-55230858 (+)
CBA/J	MGP_CBAJ_G0035459	protein coding gene	ChrX:73487784-73491879 (+)
DBA/2J	MGP_DBA2J_G0035616	protein coding gene	ChrX:69070515-69074610 (+)
FVB/NJ	MGP_FVBNJ_G0035560	protein coding gene	ChrX:68398042-68402137 (+)
LP/J	MGP_LPJ_G0035701	protein coding gene	ChrX:70192609-70196710 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035598	protein coding gene	ChrX:76075909-76080004 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036331	protein coding gene	ChrX:69231397-69235498 (+)
PWK/PhJ	MGP_PWKPhJ_G0034474	protein coding gene	ChrX:53243047-53247103 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034308	protein coding gene	ChrX:56137097-56141205 (+)
WSB/EiJ	MGP_WSBEiJ_G0034916	protein coding gene	ChrX:68500603-68504700 (+)

Human Ortholog

DUSP9, dual specificity phosphatase 9

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP9, dual specificity phosphatase 9
Synonyms

MKP-4, MKP4
Links

HGNC:3076

NCBI Gene ID: 1852

neXtProt AC: NX_Q99956

UniProt: Q99956
Chr Location

Xq28; chrX:153642441-153651326 (+) GRCh38

MGI Vertebrate Homology

Dusp9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DUSP9
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp9

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice.

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All GO Annotations

10
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

991
Tissues

183
cDNA Data

47
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp9

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All Sequences

42
RefSeq

6
UniProt

1
CCDS

CCDS30206.1

Ensembl

ENSMUSG00000031383 (Evidence)
NCBI Gene

75590

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031383	Ensembl Gene Model \| MGI Sequence Detail	4096	C57BL/6J	± kb
transcript	ENSMUST00000019701	Ensembl \| MGI Sequence Detail	2722	Not Applicable
polypeptide	ENSMUSP00000019701	Ensembl \| MGI Sequence Detail	452	Not Applicable

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UniProt

1 Sequence
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 52

Genomic 1

cDNA 47

Primer pair 3

Other 1

Microarray probesets 12

Summaries

All 39

Developmental Gene Expression 12

Gene Ontology 2

Phenotypes 10
Earliest

J:76596 Dickinson RJ, et al., Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J. 2002 May 15;364(Pt 1):145-55
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dusp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161261	ChrX:72682994-72683001 (+)	-27 bp
Tssr161262	ChrX:72683004-72683016 (+)	-15 bp
Tssr161263	ChrX:72683020-72683042 (+)	6 bp
Tssr161264	ChrX:72683045-72683048 (+)	22 bp
Tssr161265	ChrX:72683723-72683735 (+)	704 bp
Tssr161266	ChrX:72683767-72683778 (+)	748 bp
Tssr161267	ChrX:72683784-72683792 (+)	763 bp
Tssr161268	ChrX:72683976-72683983 (+)	955 bp
Tssr161269	ChrX:72684357-72684388 (+)	1,348 bp
Tssr161270	ChrX:72685056-72685068 (+)	2,037 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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