Tmem18 MGI Mouse Gene Detail - MGI:2387176

Symbol

Tmem18
Name

transmembrane protein 18

Feature Type

protein coding gene
IDs

MGI:2387176
NCBI Gene: 211986
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:30634442-30641218 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.00 cM
Mapping Data

1 experiment

SNPs within 2kb

257 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387176	protein coding gene	Chr12:30634425-30641218 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019652	protein coding gene	Chr12:28492721-28499116 (+)
A/J	MGP_AJ_G0019619	protein coding gene	Chr12:27706911-27713660 (+)
AKR/J	MGP_AKRJ_G0019590	protein coding gene	Chr12:28602497-28609246 (+)
BALB/cJ	MGP_BALBcJ_G0019596	protein coding gene	Chr12:27949567-27956316 (+)
C3H/HeJ	MGP_C3HHeJ_G0019400	protein coding gene	Chr12:28462238-28468987 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020043	protein coding gene	Chr12:29380191-29386961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017668	protein coding gene	Chr12:27030360-27037199 (+)
CAST/EiJ	MGP_CASTEiJ_G0018955	protein coding gene	Chr12:23455658-23462406 (+)
CBA/J	MGP_CBAJ_G0019371	protein coding gene	Chr12:30338577-30345326 (+)
DBA/2J	MGP_DBA2J_G0019485	protein coding gene	Chr12:27544067-27550816 (+)
FVB/NJ	MGP_FVBNJ_G0019476	protein coding gene	Chr12:27348611-27355360 (+)
LP/J	MGP_LPJ_G0019555	protein coding gene	Chr12:28590993-28597742 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019511	protein coding gene	Chr12:29962577-29969326 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020083	protein coding gene	Chr12:28130896-28137645 (+)
PWK/PhJ	MGP_PWKPhJ_G0018722	protein coding gene	Chr12:22276380-22283158 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018510	protein coding gene	Chr12:22746700-22753454 (+)
WSB/EiJ	MGP_WSBEiJ_G0019006	protein coding gene	Chr12:28356736-28363131 (+)

Human Ortholog

TMEM18, transmembrane protein 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM18, transmembrane protein 18
Synonyms

lncND
Links

HGNC:25257

NCBI Gene ID: 129787

neXtProt AC: NX_Q96B42

UniProt: Q96B42
Chr Location

2p25.3; chr2:663877-677406 (-) GRCh38

MGI Vertebrate Homology

Tmem18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM18
Gene Tree

Tmem18

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

1
Targeted

6
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a male-specific increase in body weight, fat mass and lean mass whether fed standard chow or a high-fat diet, increased suseptibility to diet-induced obesity, increased energy expenditure and increased food intake.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

2
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem18

ZFIN tmem18

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS49043.1

Ensembl

ENSMUSG00000043061 (Evidence)
NCBI Gene

211986

			Length	Strain/Species	Flank
genomic	211986	NCBI Gene Model \| MGI Sequence Detail	6777	C57BL/6J	± kb
transcript	NM_172049	RefSeq \| MGI Sequence Detail	2971	C57BL/6
polypeptide	Q3TUD9	UniProt \| EBI \| MGI Sequence Detail	140	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030524 transmembrane protein 18

(term hierarchy)
InterPro Domains

IPR026721 Transmembrane protein 18

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All nucleic 10

cDNA 10

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 10
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113088	Chr12:30634428-30634465 (+)	5 bp
Tssr113089	Chr12:30634472-30634490 (+)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24