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Ano2 Gene Detail
Summary
  • Symbol
    Ano2
  • Name
    anoctamin 2
  • Synonyms
    MGC:38715, Tmem16b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387214
    NCBI Gene: 243634
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125667382-126017089 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8899 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387214
 protein coding gene Chr6:125667382-126017115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031300
 protein coding gene Chr6:129072292-129436017 (+)
A/J MGP_AJ_G0031271
 protein coding gene Chr6:124185399-124541811 (+)
AKR/J MGP_AKRJ_G0031199
 protein coding gene Chr6:127583657-127925892 (+)
BALB/cJ MGP_BALBcJ_G0031278
 protein coding gene Chr6:123772122-124120954 (+)
C3H/HeJ MGP_C3HHeJ_G0031002
 protein coding gene Chr6:127672029-128032128 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031735
 protein coding gene Chr6:132469003-132839020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028883
 protein coding gene Chr6:121398724-121743039 (+)
CAST/EiJ MGP_CASTEiJ_G0030383
 protein coding gene Chr6:127867175-128229731 (+)
CBA/J MGP_CBAJ_G0030963
 protein coding gene Chr6:137556955-137946615 (+)
DBA/2J MGP_DBA2J_G0031119
 protein coding gene Chr6:123101584-123446481 (+)
FVB/NJ MGP_FVBNJ_G0031068
 protein coding gene Chr6:122020611-122368372 (+)
LP/J MGP_LPJ_G0031199
 protein coding gene Chr6:129215423-129579219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031107
 protein coding gene Chr6:141554238-141928202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031770
 protein coding gene Chr6:127503017-127854565 (+)
PWK/PhJ MGP_PWKPhJ_G0030098
 protein coding gene Chr6:121355675-121695309 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029927
 protein coding gene Chr6:125563773-125919176 (+)
WSB/EiJ MGP_WSBEiJ_G0030468
 protein coding gene Chr6:127855702-128234575 (+)



Homology
more
  • Human Ortholog
    ANO2, anoctamin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANO2, anoctamin 2
  • Synonyms
    C12orf3, TMEM16B
  • Links
    NCBI Gene ID: 57101
    neXtProt AC: NX_Q9NQ90
    UniProt: Q9NQ90

  • Chr Location
    12p13.31; chr12:5531869-5946232 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038115 Ensembl Gene Model | MGI Sequence Detail 349708 C57BL/6J ±  kb
    transcript ENSMUST00000160496 Ensembl | MGI Sequence Detail 3925 Not Applicable  
    polypeptide ENSMUSP00000125303 Ensembl | MGI Sequence Detail 1002 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 15
      Phenotypes 23
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory