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Gab3 Gene Detail
Summary
  • Symbol
    Gab3
  • Name
    growth factor receptor bound protein 2-associated protein 3
  • Synonyms
    5930433H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387324
    NCBI Gene: 210710
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74032151-74128511 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1336 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387324
 protein coding gene ChrX:74010449-74129064 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0035839
 protein coding gene ChrX:71019806-71122388 (-)
AKR/J MGP_AKRJ_G0035760
 protein coding gene ChrX:72894384-73005814 (-)
BALB/cJ MGP_BALBcJ_G0035821
 protein coding gene ChrX:70046313-70146728 (-)
C3H/HeJ MGP_C3HHeJ_G0035531
 protein coding gene ChrX:71295211-71392455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036351
 protein coding gene ChrX:73070829-73202412 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0035504
 protein coding gene ChrX:75034570-75156467 (-)
DBA/2J MGP_DBA2J_G0035662
 protein coding gene ChrX:70496427-70603437 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0034514
 protein coding gene ChrX:54631483-54755229 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034956
 protein coding gene ChrX:69911811-70010372 (-)



Homology
more
  • Human Ortholog
    GAB3, GRB2 associated binding protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAB3, GRB2 associated binding protein 3
  • Links
    NCBI Gene ID: 139716
    neXtProt AC: NX_Q8WWW8
    UniProt: Q8WWW8

  • Chr Location
    Xq28; chrX:154675249-154751583 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females homozygous and males hemizygous for disruptions in this X-linked gene developed normally, exhibited normal hematopoiesis, and were immunocompetent. Homozygosity for a KO or critical point mutation affects NK cell function and increases pregnancy/birth failures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 210710 NCBI Gene Model | MGI Sequence Detail 96361 C57BL/6J ±  kb
transcript NM_181584 RefSeq | MGI Sequence Detail 2129 C57BL/6  
polypeptide Q8BSM5 UniProt | EBI | MGI Sequence Detail 595 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:2445045
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:78670 Wolf I, et al., Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Mol Cell Biol. 2002 Jan;22(1):231-44
  • Latest
    J:294682 Wang Z, et al., Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8(+) T-Cell Activation. Front Immunol. 2019;10:486
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory