Olfm3 MGI Mouse Gene Detail - MGI:2387329

Symbol

Olfm3
Name

olfactomedin 3
Synonyms

B230206G02Rik, optimedin

Feature Type

protein coding gene
IDs

MGI:2387329
NCBI Gene: 229759
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:114697727-114919371 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 49.43 cM
Mapping Data

2 experiments

SNPs within 2kb

6433 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387329	protein coding gene	Chr3:114697727-114919413 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027802	protein coding gene	Chr3:116732076-116960795 (+)
A/J	MGP_AJ_G0027760	protein coding gene	Chr3:112921005-113133304 (+)
AKR/J	MGP_AKRJ_G0027726	protein coding gene	Chr3:115779341-115999846 (+)
BALB/cJ	MGP_BALBcJ_G0027772	protein coding gene	Chr3:112774357-112989829 (+)
C3H/HeJ	MGP_C3HHeJ_G0027503	protein coding gene	Chr3:116143920-116361511 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028218	protein coding gene	Chr3:121041755-121281404 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025557	protein coding gene	Chr3:108665135-108880102 (+)
CAST/EiJ	MGP_CASTEiJ_G0026959	protein coding gene	Chr3:115396245-115625104 (+)
CBA/J	MGP_CBAJ_G0027478	protein coding gene	Chr3:125175886-125414080 (+)
DBA/2J	MGP_DBA2J_G0027619	protein coding gene	Chr3:112172503-112385188 (+)
FVB/NJ	MGP_FVBNJ_G0027587	protein coding gene	Chr3:109830255-110043562 (+)
LP/J	MGP_LPJ_G0027729	protein coding gene	Chr3:118290591-118511002 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027617	protein coding gene	Chr3:132455546-132747088 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028274	protein coding gene	Chr3:115332119-115554527 (+)
PWK/PhJ	MGP_PWKPhJ_G0026685	protein coding gene	Chr3:111789278-112013256 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026507	protein coding gene	Chr3:113334238-113573408 (+)
WSB/EiJ	MGP_WSBEiJ_G0027039	protein coding gene	Chr3:115986619-116216127 (+)

Human Ortholog

OLFM3, olfactomedin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OLFM3, olfactomedin 3
Synonyms

NOE3, NOELIN3, OPTIMEDIN
Links

HGNC:17990

NCBI Gene ID: 118427

neXtProt AC: NX_Q96PB7

UniProt: Q96PB7
Chr Location

1p21.1; chr1:101802560-101996926 (-) GRCh38

MGI Vertebrate Homology

Olfm3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OLFM3
Gene Tree

Olfm3

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References

1 with disease annotations

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Olfm3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

10
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA OLFM3

Xenbase olfm3

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS17779.1, CCDS17780.1

Ensembl

ENSMUSG00000027965 (Evidence)
NCBI Gene

229759

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027965	Ensembl Gene Model \| MGI Sequence Detail	221645	C57BL/6J	± kb
transcript	ENSMUST00000051309	Ensembl \| MGI Sequence Detail	3928	Not Applicable
polypeptide	ENSMUSP00000060985	Ensembl \| MGI Sequence Detail	478	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011625 noelin-3

(term hierarchy)
InterPro Domains

IPR022082 Noelin domain

IPR003112 Olfactomedin-like domain

IPR050605 Olfactomedin-like domain-containing protein

IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
GlyGen

P63056 7 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

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All nucleic 12

cDNA 9

Primer pair 3

Microarray probesets 5

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MGI:2443850

Summaries

All 30

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 7
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:341089 Boudkkazi S, et al., A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors. Neuron. 2023 Aug 16;111(16):2544-2556.e9

TSS for Olfm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31320	Chr3:114697711-114697791 (+)	24 bp
Tssr31321	Chr3:114697862-114697873 (+)	141 bp
Tssr31322	Chr3:114697887-114697914 (+)	174 bp
Tssr31323	Chr3:114697915-114697940 (+)	201 bp
Tssr31324	Chr3:114698001-114698030 (+)	289 bp
Tssr31325	Chr3:114698117-114698129 (+)	396 bp
Tssr31326	Chr3:114707262-114707265 (+)	9,537 bp
Tssr31327	Chr3:114874674-114874685 (+)	176,953 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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