Wac MGI Mouse Gene Detail - MGI:2387357 - WW domain containing adaptor with coiled-coil

Symbol

Wac
Name

WW domain containing adaptor with coiled-coil
Synonyms

1110067P07Rik, A230035H12Rik, Wwp4

Feature Type

protein coding gene
IDs

MGI:2387357
NCBI Gene: 225131
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr18:7868832-7929028 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.62 cM
Mapping Data

3 experiments

SNPs within 2kb

1394 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387357	protein coding gene	Chr18:7868614-7929028 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024136	protein coding gene	Chr18:4757220-4873489 (+)
A/J	MGP_AJ_G0024098	protein coding gene	Chr18:4791405-4897047 (+)
AKR/J	MGP_AKRJ_G0024066	protein coding gene	Chr18:4870861-4977568 (+)
BALB/cJ	MGP_BALBcJ_G0024098	protein coding gene	Chr18:4714971-4818138 (+)
C3H/HeJ	MGP_C3HHeJ_G0023864	protein coding gene	Chr18:4775033-4882042 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024543	protein coding gene	Chr18:5095470-5205554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021982	protein coding gene	Chr18:4453148-4510021 (+)
CAST/EiJ	MGP_CASTEiJ_G0023342	protein coding gene	Chr18:4777783-4891204 (+)
CBA/J	MGP_CBAJ_G0023837	protein coding gene	Chr18:5015713-5128452 (+)
DBA/2J	MGP_DBA2J_G0023965	protein coding gene	Chr18:4608358-4713299 (+)
FVB/NJ	MGP_FVBNJ_G0023931	protein coding gene	Chr18:4609139-4718088 (+)
LP/J	MGP_LPJ_G0024049	protein coding gene	Chr18:4799840-4907082 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023959	protein coding gene	Chr18:5145456-5261149 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024588	protein coding gene	Chr18:4731861-4833253 (+)
PWK/PhJ	MGP_PWKPhJ_G0023087	protein coding gene	Chr18:4678407-4780919 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022898	protein coding gene	Chr18:5007734-5115197 (+)
WSB/EiJ	MGP_WSBEiJ_G0023408	protein coding gene	Chr18:4722385-4832200 (+)

Human Ortholog

WAC, WW domain containing adaptor with coiled-coil

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WAC, WW domain containing adaptor with coiled-coil
Synonyms

BM-016, DESSH, PRO1741, Wwp4
Links

HGNC:17327

NCBI Gene ID: 51322

neXtProt AC: NX_Q9BTA9

UniProt: Q9BTA9
Chr Location

10p12.1-p11.2; chr10:28532493-28623112 (+) GRCh38

MGI Vertebrate Homology

Wac stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WAC
Gene Tree

Wac

Diseases

1 with human WAC associations

				Human Disease	Mouse Models
				DeSanto-Shinawi syndrome IDs DeSanto-Shinawi syndrome DOID:0081126 OMIM:616708 ORDO:284169 ORDO:466943 ORDO:466950

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Endonuclease-mediated

3
Gene trapped

38
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

35
cDNA Data

22
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wac

ZFIN waca

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All Sequences

123
RefSeq

28
UniProt

11
CCDS

CCDS29046.1, CCDS50218.1, CCDS70869.1

Ensembl

ENSMUSG00000024283 (Evidence)
NCBI Gene

225131

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024283	Ensembl Gene Model \| MGI Sequence Detail	60197	C57BL/6J	± kb
transcript	ENSMUST00000167020	Ensembl \| MGI Sequence Detail	5208	Not Applicable
polypeptide	ENSMUSP00000132117	Ensembl \| MGI Sequence Detail	646	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000031681 WW domain-containing adapter protein with coiled-coil

(term hierarchy)
InterPro Domains

IPR001202 WW domain

IPR038867 WW domain-containing adapter protein with coiled-coil

IPR036020 WW domain superfamily
GlyGen

Q924H7 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 5

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MGI:1923581, MGI:2147203, MGI:2147204

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wac:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149978	Chr18:7868473-7868494 (+)	-348 bp
Tssr149979	Chr18:7868823-7868862 (+)	11 bp
Tssr149980	Chr18:7868877-7868888 (+)	51 bp
Tssr149981	Chr18:7869139-7869152 (+)	314 bp
Tssr149982	Chr18:7869159-7869209 (+)	352 bp
Tssr149983	Chr18:7869214-7869226 (+)	388 bp
Tssr149984	Chr18:7869307-7869329 (+)	486 bp
Tssr149985	Chr18:7869342-7869381 (+)	530 bp
Tssr149986	Chr18:7869707-7869727 (+)	885 bp
Tssr149987	Chr18:7869875-7869898 (+)	1,055 bp
Tssr149988	Chr18:7877543-7877584 (+)	8,732 bp
Tssr149989	Chr18:7901490-7901506 (+)	32,666 bp
Tssr149990	Chr18:7905440-7905459 (+)	36,618 bp
Tssr149991	Chr18:7916018-7916034 (+)	47,194 bp
Tssr149992	Chr18:7916114-7916130 (+)	47,290 bp
Tssr5242	Chr18:7926033-7926038 (+)	57,204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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