Ppp1r9b MGI Mouse Gene Detail - MGI:2387581 - protein phosphatase 1, regulatory subunit 9B

Symbol

Ppp1r9b
Name

protein phosphatase 1, regulatory subunit 9B
Synonyms

MGC:38940, neurabin II, spinophilin, SPL, Spn

Feature Type

protein coding gene
IDs

MGI:2387581
NCBI Gene: 217124
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:94882038-94897724 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

1 experiment

SNPs within 2kb

374 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387581	protein coding gene	Chr11:94881861-94897725 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018973	protein coding gene	Chr11:97175198-97191061 (+)
A/J	MGP_AJ_G0018941	protein coding gene	Chr11:93249506-93265395 (+)
AKR/J	MGP_AKRJ_G0018911	protein coding gene	Chr11:96133508-96149397 (+)
BALB/cJ	MGP_BALBcJ_G0018914	protein coding gene	Chr11:93722202-93738065 (+)
C3H/HeJ	MGP_C3HHeJ_G0018728	protein coding gene	Chr11:96261505-96277394 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019366	protein coding gene	Chr11:100239326-100255186 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016997	protein coding gene	Chr11:90736731-90752676 (+)
CAST/EiJ	MGP_CASTEiJ_G0018282	protein coding gene	Chr11:97050773-97067358 (+)
CBA/J	MGP_CBAJ_G0018699	protein coding gene	Chr11:104324496-104340385 (+)
DBA/2J	MGP_DBA2J_G0018807	protein coding gene	Chr11:92825585-92841445 (+)
FVB/NJ	MGP_FVBNJ_G0018796	protein coding gene	Chr11:92287002-92302866 (+)
LP/J	MGP_LPJ_G0018877	protein coding gene	Chr11:97736201-97752119 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018823	protein coding gene	Chr11:104384389-104400251 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019406	protein coding gene	Chr11:96396371-96412231 (+)
PWK/PhJ	MGP_PWKPhJ_G0018053	protein coding gene	Chr11:93737179-93753153 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017842	protein coding gene	Chr11:96075962-96091831 (+)
WSB/EiJ	MGP_WSBEiJ_G0018331	protein coding gene	Chr11:96315069-96330929 (+)

Human Ortholog

PPP1R9B, protein phosphatase 1 regulatory subunit 9B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R9B, protein phosphatase 1 regulatory subunit 9B
Synonyms

PPP1R6, PPP1R9, SPINO, Spn
Links

HGNC:9298

NCBI Gene ID: 84687

neXtProt AC: NX_Q96SB3

UniProt: Q96SB3
Chr Location

17q21.33

MGI Vertebrate Homology

Ppp1r9b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP1R9B
Gene Tree

Ppp1r9b

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Targeted

8
Genomic Mutations

2 involving Ppp1r9b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit abnormal glutamatergic synaptic transmission, reduced long-term depression, resistance to kainate-induced seizures, impaired taste aversion learning, and increased dendritic spine density.

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All GO Annotations

105
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

83
cDNA Data

7
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r9b

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS25268.1

Ensembl

ENSMUSG00000038976 (Evidence)
NCBI Gene

217124

			Length	Strain/Species	Flank
genomic	217124	NCBI Gene Model \| MGI Sequence Detail	15687	C57BL/6J	± kb
transcript	NM_172261	RefSeq \| MGI Sequence Detail	4345	C57BL/6
polypeptide	Q6R891	UniProt \| EBI \| MGI Sequence Detail	817	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013133 neurabin-2

(term hierarchy)
InterPro Domains

IPR040645 Neurabin-1/2, PDZ domain

IPR043446 Neurabin-like family

IPR001478 PDZ domain

IPR036034 PDZ superfamily
GlyGen

Q6R891 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 9

Genomic 1

cDNA 7

Other 1

Microarray probesets 3

Summaries

All 71

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 39
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:358643 Stickel KC, et al., Mechanisms of spinophilin-dependent pancreas dysregulation in obesity. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E155-E171

TSS for Ppp1r9b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104318	Chr11:94881585-94881623 (+)	-434 bp
Tssr104319	Chr11:94881750-94881796 (+)	-265 bp
Tssr104320	Chr11:94881797-94881821 (+)	-229 bp
Tssr104321	Chr11:94881822-94881838 (+)	-208 bp
Tssr3648	Chr11:94881868-94881916 (+)	-146 bp
Tssr3650	Chr11:94882011-94882045 (+)	-10 bp
Tssr104322	Chr11:94882200-94882214 (+)	169 bp
Tssr104323	Chr11:94884400-94884418 (+)	2,371 bp
Tssr3651	Chr11:94888686-94888705 (+)	6,658 bp
Tssr104324	Chr11:94888725-94888750 (+)	6,700 bp
Tssr104325	Chr11:94897149-94897161 (+)	15,117 bp
Tssr104326	Chr11:94897176-94897195 (+)	15,148 bp
Tssr104327	Chr11:94897258-94897283 (+)	15,233 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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