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Zfp280c Gene Detail
Summary
  • Symbol
    Zfp280c
  • Name
    zinc finger protein 280C
  • Synonyms
    MGC:38010, mKIAA1584, Suhw3, Zfp633
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387585
    NCBI Gene: 208968
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:47630502-47683381 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387585
 protein coding gene ChrX:47630502-47683599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035695
 protein coding gene ChrX:43707099-43760182 (-)
A/J MGP_AJ_G0035678
 protein coding gene ChrX:43563912-43627515 (-)
AKR/J MGP_AKRJ_G0035598
 protein coding gene ChrX:44778794-44833821 (-)
BALB/cJ MGP_BALBcJ_G0035664
 protein coding gene ChrX:43212875-43266181 (-)
C3H/HeJ MGP_C3HHeJ_G0035368
 protein coding gene ChrX:43999789-44052255 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036193
 protein coding gene ChrX:44734546-44787570 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033045
 protein coding gene ChrX:41253575-41302734 (-)
CAST/EiJ MGP_CASTEiJ_G0034659
 protein coding gene ChrX:31573563-31630603 (-)
CBA/J MGP_CBAJ_G0035342
 protein coding gene ChrX:45993407-46048822 (-)
DBA/2J MGP_DBA2J_G0035496
 protein coding gene ChrX:43400711-43453257 (-)
FVB/NJ MGP_FVBNJ_G0035445
 protein coding gene ChrX:43119953-43173059 (-)
LP/J MGP_LPJ_G0035584
 protein coding gene ChrX:44059230-44112219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035483
 protein coding gene ChrX:47422669-47476751 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036211
 protein coding gene ChrX:43601647-43659904 (-)
PWK/PhJ MGP_PWKPhJ_G0034358
 protein coding gene ChrX:31053517-31106876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034203
 protein coding gene ChrX:32381723-32437196 (-)
WSB/EiJ MGP_WSBEiJ_G0034803
 protein coding gene ChrX:43244862-43298249 (-)



Homology
more
  • Human Ortholog
    ZNF280C, zinc finger protein 280C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF280C, zinc finger protein 280C
  • Synonyms
    SUHW3, ZNF633, ZPET
  • Links
    NCBI Gene ID: 55609
    neXtProt AC: NX_Q8ND82
    UniProt: Q8ND82

  • Chr Location
    Xq26.1; chrX:130202707-130268899 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show reduced tumor burden and decreased high-grade adenomas following AOM/DSS induced colitis-associated cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    11
  • cDNA Data
    26
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036916 Ensembl Gene Model | MGI Sequence Detail 52880 C57BL/6J ±  kb
    transcript ENSMUST00000088898 Ensembl | MGI Sequence Detail 4024 Not Applicable  
    polypeptide ENSMUSP00000086288 Ensembl | MGI Sequence Detail 742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:331404 Ying Y, et al., Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2120633119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory