Tns2 MGI Mouse Gene Detail - MGI:2387586

Symbol

Tns2
Name

tensin 2
Synonyms

nep, nph, Tenc1

Feature Type

protein coding gene
IDs

MGI:2387586
NCBI Gene: 209039
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr15:102008848-102024836 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.29 cM
Mapping Data

3 experiments

SNPs within 2kb

333 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387586	protein coding gene	Chr15:102006910-102024836 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022398	protein coding gene	Chr15:104243215-104256628 (+)
A/J	MGP_AJ_G0022360	protein coding gene	Chr15:100162309-100175921 (+)
AKR/J	MGP_AKRJ_G0022335	protein coding gene	Chr15:103193521-103206934 (+)
BALB/cJ	MGP_BALBcJ_G0022364	protein coding gene	Chr15:100205840-100219253 (+)
C3H/HeJ	MGP_C3HHeJ_G0022131	protein coding gene	Chr15:103264512-103278187 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022813	protein coding gene	Chr15:108131489-108144902 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020336	protein coding gene	Chr15:95937926-95951608 (+)
CAST/EiJ	MGP_CASTEiJ_G0021657	protein coding gene	Chr15:104121433-104134861 (+)
CBA/J	MGP_CBAJ_G0022100	protein coding gene	Chr15:111907723-111921350 (+)
DBA/2J	MGP_DBA2J_G0022231	protein coding gene	Chr15:99449224-99462637 (+)
FVB/NJ	MGP_FVBNJ_G0022207	protein coding gene	Chr15:98504793-98518206 (+)
LP/J	MGP_LPJ_G0022300	protein coding gene	Chr15:104408495-104421908 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022229	protein coding gene	Chr15:115508397-115521810 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022825	protein coding gene	Chr15:103213315-103226728 (+)
PWK/PhJ	MGP_PWKPhJ_G0021397	protein coding gene	Chr15:99597843-99611265 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021229	protein coding gene	Chr15:103060604-103074003 (+)
WSB/EiJ	MGP_WSBEiJ_G0021707	protein coding gene	Chr15:103841342-103854984 (+)

Human Ortholog

TNS2, tensin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNS2, tensin 2
Synonyms

C1-TEN, C1TEN, TENC1
Links

HGNC:19737

NCBI Gene ID: 23371

neXtProt AC: NX_Q63HR2

UniProt: Q63HR2
Chr Location

12q13.13; chr12:53046969-53064379 (+) GRCh38

MGI Vertebrate Homology

Tns2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNS2
Gene Tree

Tns2

Diseases

1 with Tns2 mouse models

Human Disease

Mouse Models

Pierson syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Tns2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

116 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

28
cDNA Data

71
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

14
UniProt

3
CCDS

CCDS37224.1, CCDS88852.1

Ensembl

ENSMUSG00000037003 (Evidence)
NCBI Gene

209039

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037003	Ensembl Gene Model \| MGI Sequence Detail	15989	C57BL/6J	± kb
transcript	ENSMUST00000046144	Ensembl \| MGI Sequence Detail	4718	Not Applicable
polypeptide	ENSMUSP00000041087	Ensembl \| MGI Sequence Detail	1407	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016232 tensin-2

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR046349 C1-like domain superfamily

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR011993 PH-like domain superfamily

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR029021 Protein-tyrosine phosphatase-like

IPR006020 PTB/PI domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR013625 Tensin/EPS8 phosphotyrosine-binding domain

IPR035012 Tensin-like, SH2 domain

IPR051484 Tensin Phosphatase

IPR014020 Tensin phosphatase, C2 domain

IPR033929 Tensin, phosphotyrosine-binding domain

IPR029023 Tensin-type phosphatase domain
GlyGen

Q8CGB6 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 71

cDNA 71

Microarray probesets 3

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MGI:1096861

Summaries

All 86

Developmental Gene Expression 3

Diseases 2

Gene Ontology 10

Phenotypes 55
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:321844 Mochida Y, et al., Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. Sci Rep. 2022 Mar 10;12(1):4197

TSS for Tns2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133323	Chr15:102006878-102006933 (+)	-1,942 bp
Tssr133324	Chr15:102008800-102008819 (+)	-38 bp
Tssr133325	Chr15:102008829-102008858 (+)	-4 bp
Tssr133326	Chr15:102010633-102010677 (+)	1,807 bp
Tssr133327	Chr15:102011361-102011410 (+)	2,538 bp
Tssr4736	Chr15:102011415-102011420 (+)	2,570 bp
Tssr133328	Chr15:102011511-102011518 (+)	2,667 bp
Tssr133329	Chr15:102012782-102012793 (+)	3,940 bp
Tssr133330	Chr15:102012796-102012808 (+)	3,954 bp
Tssr133331	Chr15:102012811-102012823 (+)	3,969 bp
Tssr133332	Chr15:102012824-102012853 (+)	3,991 bp
Tssr133333	Chr15:102012941-102012955 (+)	4,100 bp
Tssr133334	Chr15:102012965-102012974 (+)	4,122 bp
Tssr133335	Chr15:102013023-102013036 (+)	4,182 bp
Tssr133336	Chr15:102014585-102014598 (+)	5,744 bp
Tssr133337	Chr15:102021460-102021496 (+)	12,630 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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