Cd300e MGI Mouse Gene Detail - MGI:2387602

Symbol

Cd300e
Name

CD300E molecule
Synonyms

Cd300le, Clm2, MGC:31495, MGC:49720, Trem5

Feature Type

protein coding gene
IDs

MGI:2387602
NCBI Gene: 217306
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:114942743-114957500 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.58 cM
Mapping Data

1 experiment

SNPs within 2kb

606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387602	protein coding gene	Chr11:114942743-114957502 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019370	protein coding gene	Chr11:119045390-119055626 (-)
A/J	MGP_AJ_G0019339	protein coding gene	Chr11:113850992-113861348 (-)
AKR/J	MGP_AKRJ_G0019309	protein coding gene	Chr11:117247082-117257072 (-)
BALB/cJ	MGP_BALBcJ_G0019313	protein coding gene	Chr11:114271356-114281569 (-)
C3H/HeJ	MGP_C3HHeJ_G0019119	protein coding gene	Chr11:117603391-117613542 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019763	protein coding gene	Chr11:122680174-122691995 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017385	protein coding gene	Chr11:110900766-110911055 (-)
CAST/EiJ	MGP_CASTEiJ_G0018674	protein coding gene	Chr11:118901604-118914888 (-)
CBA/J	MGP_CBAJ_G0019091	protein coding gene	Chr11:127521410-127534490 (-)
DBA/2J	MGP_DBA2J_G0019202	protein coding gene	Chr11:113292639-113302642 (-)
FVB/NJ	MGP_FVBNJ_G0019194	protein coding gene	Chr11:112761547-112772527 (-)
LP/J	MGP_LPJ_G0019272	protein coding gene	Chr11:119422077-119432233 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019227	protein coding gene	Chr11:126715641-126725986 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019801	protein coding gene	Chr11:117905663-117916897 (-)
PWK/PhJ	MGP_PWKPhJ_G0018438	protein coding gene	Chr11:114562110-114577574 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018230	protein coding gene	Chr11:117665583-117678613 (-)
WSB/EiJ	MGP_WSBEiJ_G0018726	protein coding gene	Chr11:117849999-117862594 (-)

Human Ortholog

CD300E, CD300e molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD300E, CD300e molecule
Synonyms

CD300LE, CLM-2, CLM2, CMRF35-A5, IREM-2, IREM2, PIgR-2, PIgR2
Links

HGNC:28874

NCBI Gene ID: 342510

neXtProt AC: NX_Q496F6

UniProt: Q496F6
Chr Location

17q25.1; chr17:74609878-74623738 (-) GRCh38

MGI Vertebrate Homology

Cd300e stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD300E
Gene Tree

Cd300e

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS25618.1

Ensembl

ENSMUSG00000048498 (Evidence)
NCBI Gene

217306

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048498	Ensembl Gene Model \| MGI Sequence Detail	14758	C57BL/6J	± kb
transcript	ENSMUST00000062787	Ensembl \| MGI Sequence Detail	2185	Not Applicable
polypeptide	ENSMUSP00000054883	Ensembl \| MGI Sequence Detail	196	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001413 CMRF35-like molecule 2

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q8K249 1 site

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 6
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cd300e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111721	Chr11:114957517-114957537 (-)	-27 bp
Tssr111720	Chr11:114957478-114957495 (-)	13 bp
Tssr111719	Chr11:114952984-114952995 (-)	4,510 bp
Tssr111718	Chr11:114952950-114952982 (-)	4,534 bp
Tssr111717	Chr11:114952935-114952947 (-)	4,559 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24