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Tmem63b Gene Detail
Summary
  • Symbol
    Tmem63b
  • Name
    transmembrane protein 63b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387609
    NCBI Gene: 224807
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45971102-45997212 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    729 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387609
 protein coding gene Chr17:45971097-45997831 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023797
 protein coding gene Chr17:46684309-46713358 (-)
A/J MGP_AJ_G0023755
 protein coding gene Chr17:45563800-45592015 (-)
AKR/J MGP_AKRJ_G0023726
 protein coding gene Chr17:45885963-45913641 (-)
BALB/cJ MGP_BALBcJ_G0023759
 protein coding gene Chr17:45449628-45476240 (-)
C3H/HeJ MGP_C3HHeJ_G0023523
 protein coding gene Chr17:46595107-46625608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024202
 protein coding gene Chr17:48699705-48739240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021652
 protein coding gene Chr17:42355501-42382700 (-)
CAST/EiJ MGP_CASTEiJ_G0023004
 protein coding gene Chr17:46694080-46722111 (-)
CBA/J MGP_CBAJ_G0023499
 protein coding gene Chr17:50433320-50463006 (-)
DBA/2J MGP_DBA2J_G0023625
 protein coding gene Chr17:44355139-44381952 (-)
FVB/NJ MGP_FVBNJ_G0023592
 protein coding gene Chr17:43931634-43958762 (-)
LP/J MGP_LPJ_G0023706
 protein coding gene Chr17:47334120-47363293 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023621
 protein coding gene Chr17:49991402-50020593 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024247
 protein coding gene Chr17:46241633-46272686 (-)
PWK/PhJ MGP_PWKPhJ_G0022749
 protein coding gene Chr17:43665396-43692395 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022564
 protein coding gene Chr17:43110951-43137632 (-)
WSB/EiJ MGP_WSBEiJ_G0023069
 protein coding gene Chr17:46767346-46795943 (-)



Homology
more
  • Human Ortholog
    TMEM63B, transmembrane protein 63B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM63B, transmembrane protein 63B
  • Synonyms
    C6orf110
  • Links
    NCBI Gene ID: 55362
    neXtProt AC: NX_Q5T3F8
    UniProt: Q5T3F8

  • Chr Location
    6p21.1; chr6:44126633-44155519 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit progressive hearing loss leading to deafness, with cochlear outer hair cell necroptosis, degeneration and impaired hypo-osmolarity-activated currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    16
  • cDNA Data
    113
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224807 NCBI Gene Model | MGI Sequence Detail 26111 C57BL/6J ±  kb
    transcript NM_001413623 RefSeq | MGI Sequence Detail 3476 C57BL/6  
    polypeptide Q3TWI9 UniProt | EBI | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000032717 CSC1-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR045122 Calcium permeable stress-gated cation channel 1-like
      IPR003864 CSC1/OSCA1-like, 7TM region
      IPR027815 CSC1/OSCA1-like, cytosolic domain
      IPR032880 CSC1/OSCA1-like, N-terminal transmembrane domain
    • GlyGen
      Q3TWI9 3 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 113

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:348247 Dalghi MG, et al., Expression and localization of the mechanosensitive/osmosensitive ion channel TMEM63B in the mouse urinary tract. Physiol Rep. 2024 May;12(9):e16043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory