Eml3 MGI Mouse Gene Detail - MGI:2387612 - echinoderm microtubule associated protein like 3

Symbol

Eml3
Name

echinoderm microtubule associated protein like 3
Synonyms

MGC:37888, MGC:38588

Feature Type

protein coding gene
IDs

MGI:2387612
NCBI Gene: 225898
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:8906916-8918946 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.04 cM
Mapping Data

1 experiment

SNPs within 2kb

331 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387612	protein coding gene	Chr19:8904584-8918946 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024824	protein coding gene	Chr19:6217416-6229175 (+)
A/J	MGP_AJ_G0024792	protein coding gene	Chr19:5882530-5894303 (+)
AKR/J	MGP_AKRJ_G0024767	protein coding gene	Chr19:5980487-5993841 (+)
BALB/cJ	MGP_BALBcJ_G0024792	protein coding gene	Chr19:5991764-6004224 (+)
C3H/HeJ	MGP_C3HHeJ_G0024558	protein coding gene	Chr19:6068684-6080723 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025239	protein coding gene	Chr19:6352929-6365139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022668	protein coding gene	Chr19:6139627-6151584 (+)
CAST/EiJ	MGP_CASTEiJ_G0024031	protein coding gene	Chr19:5718370-5731265 (+)
CBA/J	MGP_CBAJ_G0024532	protein coding gene	Chr19:6470761-6485641 (+)
DBA/2J	MGP_DBA2J_G0024659	protein coding gene	Chr19:5717320-5729428 (+)
FVB/NJ	MGP_FVBNJ_G0024626	protein coding gene	Chr19:5787568-5800758 (+)
LP/J	MGP_LPJ_G0024746	protein coding gene	Chr19:6113152-6126013 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024653	protein coding gene	Chr19:6329018-6342046 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025288	protein coding gene	Chr19:6028052-6041110 (+)
PWK/PhJ	MGP_PWKPhJ_G0023776	protein coding gene	Chr19:5390161-5402511 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023581	protein coding gene	Chr19:5638754-5652181 (+)
WSB/EiJ	MGP_WSBEiJ_G0024093	protein coding gene	Chr19:5995655-6010039 (+)

Human Ortholog

EML3, EMAP like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EML3, EMAP like 3
Synonyms

ELP95, EMAP3, EMAP95
Links

HGNC:26666

NCBI Gene ID: 256364

neXtProt AC: NX_Q32P44

UniProt: Q32P44
Chr Location

11q12.3; chr11:62602218-62612775 (-) GRCh38

MGI Vertebrate Homology

Eml3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EML3
Gene Tree

Eml3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eml3

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS29560.1

Ensembl

ENSMUSG00000071647 (Evidence)
NCBI Gene

225898

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071647	Ensembl Gene Model \| MGI Sequence Detail	12031	C57BL/6J	± kb
transcript	ENSMUST00000096241	Ensembl \| MGI Sequence Detail	3322	Not Applicable
polypeptide	ENSMUSP00000093960	Ensembl \| MGI Sequence Detail	897	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007058 echinoderm microtubule-associated protein-like 3

(term hierarchy)
InterPro Domains

IPR005108 HELP motif

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like
GlyGen

Q8VC03 1 site, 1 N-linked glycan (1 site)

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All nucleic 5

cDNA 5

Microarray probesets 3

Summaries

All 27

Gene Ontology 5

Phenotypes 6
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Eml3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154885	Chr19:8906777-8906812 (+)	-121 bp
Tssr154886	Chr19:8906814-8906841 (+)	-88 bp
Tssr154887	Chr19:8906918-8906945 (+)	16 bp
Tssr154888	Chr19:8906992-8907058 (+)	109 bp
Tssr154889	Chr19:8907205-8907230 (+)	302 bp
Tssr154890	Chr19:8909813-8909851 (+)	2,916 bp
Tssr154891	Chr19:8916920-8916923 (+)	10,006 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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