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Fam20a Gene Detail
Summary
  • Symbol
    Fam20a
  • Name
    FAM20A, golgi associated secretory pathway pseudokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388266
    NCBI Gene: 208659
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109563752-109613989 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 72.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1543 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388266
 protein coding gene Chr11:109560575-109613989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019338
 protein coding gene Chr11:113244397-113297727 (-)
A/J MGP_AJ_G0019306
 protein coding gene Chr11:108343370-108396282 (-)
AKR/J MGP_AKRJ_G0019275
 protein coding gene Chr11:111603290-111657204 (-)
BALB/cJ MGP_BALBcJ_G0019280
 protein coding gene Chr11:108774648-108827033 (-)
C3H/HeJ MGP_C3HHeJ_G0019089
 protein coding gene Chr11:111897017-111952644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019730
 protein coding gene Chr11:116672486-116726015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017353
 protein coding gene Chr11:105565904-105617494 (-)
CAST/EiJ MGP_CASTEiJ_G0018642
 protein coding gene Chr11:113036453-113094275 (-)
CBA/J MGP_CBAJ_G0019058
 protein coding gene Chr11:121489203-121545967 (-)
DBA/2J MGP_DBA2J_G0019170
 protein coding gene Chr11:107823021-107875443 (-)
FVB/NJ MGP_FVBNJ_G0019161
 protein coding gene Chr11:107308472-107361274 (-)
LP/J MGP_LPJ_G0019240
 protein coding gene Chr11:113655828-113709530 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019192
 protein coding gene Chr11:120629705-120685126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019767
 protein coding gene Chr11:112160786-112214842 (-)
PWK/PhJ MGP_PWKPhJ_G0018407
 protein coding gene Chr11:108988987-109042318 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018199
 protein coding gene Chr11:111944507-111999144 (-)
WSB/EiJ MGP_WSBEiJ_G0018694
 protein coding gene Chr11:112083631-112139807 (-)



Homology
more
  • Human Ortholog
    FAM20A, FAM20A golgi associated secretory pathway pseudokinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM20A, FAM20A golgi associated secretory pathway pseudokinase
  • Synonyms
    AI1G, AIGFS, FP2747
  • Links
    NCBI Gene ID: 54757
    neXtProt AC: NX_Q96MK3
    UniProt: Q96MK3

  • Chr Location
    17q24.2; chr17:68535113-68601367 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FAM20A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal ameloblast morphology, disrupted dental enamel formation in both incisor and molar teeth, abnormal kidney morphology, disseminated calcifications of muscular arteries, and intrapulmonary calcifications.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    40
  • cDNA Data
    68
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208659 NCBI Gene Model | MGI Sequence Detail 50238 C57BL/6J ±  kb
    transcript NM_153782 RefSeq | MGI Sequence Detail 2523 C57BL/6  
    polypeptide Q8CID3 UniProt | EBI | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144241
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:98491 Nalbant D, et al., FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC Genomics. 2005 Jan 27;6(1):11
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory