Glb1l2 MGI Mouse Gene Detail - MGI:2388283 - galactosidase, beta 1-like 2

Symbol

Glb1l2
Name

galactosidase, beta 1-like 2
Synonyms

MGC:47419

Feature Type

protein coding gene
IDs

MGI:2388283
NCBI Gene: 244757
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:26674340-26717764 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 11.56 cM
Mapping Data

1 experiment

SNPs within 2kb

1320 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388283	protein coding gene	Chr9:26674338-26717769 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034500	protein coding gene	Chr9:24202490-24245909 (-)
A/J	MGP_AJ_G0034478	protein coding gene	Chr9:23669977-23713749 (-)
AKR/J	MGP_AKRJ_G0034404	protein coding gene	Chr9:24155839-24199268 (-)
BALB/cJ	MGP_BALBcJ_G0034469	protein coding gene	Chr9:23566924-23613323 (-)
C3H/HeJ	MGP_C3HHeJ_G0034181	protein coding gene	Chr9:24520161-24564347 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034990	protein coding gene	Chr9:25106165-25149405 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031920	protein coding gene	Chr9:22596711-22639619 (-)
CAST/EiJ	MGP_CASTEiJ_G0033504	protein coding gene	Chr9:24330472-24373879 (-)
CBA/J	MGP_CBAJ_G0034154	protein coding gene	Chr9:26017920-26062554 (-)
DBA/2J	MGP_DBA2J_G0034312	protein coding gene	Chr9:23692613-23739284 (-)
FVB/NJ	MGP_FVBNJ_G0034255	protein coding gene	Chr9:23142102-23185722 (-)
LP/J	MGP_LPJ_G0034398	protein coding gene	Chr9:24401634-24450881 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034299	protein coding gene	Chr9:27701910-27751982 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035010	protein coding gene	Chr9:24123350-24166765 (-)
PWK/PhJ	MGP_PWKPhJ_G0033209	protein coding gene	Chr9:23610344-23651179 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033043	protein coding gene	Chr9:24178928-24222322 (-)
WSB/EiJ	MGP_WSBEiJ_G0033619	protein coding gene	Chr9:23863348-23908806 (-)

Human Ortholog

GLB1L2, galactosidase beta 1 like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLB1L2, galactosidase beta 1 like 2
Synonyms

MST114, MSTP114
Links

HGNC:25129

NCBI Gene ID: 89944

neXtProt AC: NX_Q8IW92

UniProt: Q8IW92
Chr Location

11q25; chr11:134331988-134378341 (+) GRCh38

MGI Vertebrate Homology

Glb1l2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GLB1L2
Protein SuperFamily

B-gal
Gene Tree

Glb1l2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Glb1l2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Homozygous mutant mice show decreased mean white blood cell and lymphocyte counts and a decreased mean percentage of natural killer cells. Male mutant mice exhibit impaired glucose tolerance.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

16
cDNA Data

57
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase glb1l2

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All Sequences

68
RefSeq

18
UniProt

6
CCDS

CCDS40566.1, CCDS80971.1

Ensembl

ENSMUSG00000036395 (Evidence)
NCBI Gene

244757

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036395	Ensembl Gene Model \| MGI Sequence Detail	43425	C57BL/6J	± kb
transcript	ENSMUST00000040398	Ensembl \| MGI Sequence Detail	3701	Not Applicable
polypeptide	ENSMUSP00000047128	Ensembl \| MGI Sequence Detail	652	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008018 beta-galactosidase-1-like protein 2

(term hierarchy)
EC

3.2.1.-, 3.2.1.23
InterPro Domains

IPR026283 Beta-galactosidase 1-like

IPR048912 Beta-galactosidase 1-like , first all-beta domain

IPR048913 Beta-galactosidase, galactose-binding domain

IPR008979 Galactose-binding-like domain superfamily

IPR031330 Glycoside hydrolase 35, catalytic domain

IPR001944 Glycoside hydrolase, family 35

IPR019801 Glycoside hydrolase, family 35, conserved site

IPR017853 Glycoside hydrolase superfamily

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All nucleic 58

cDNA 57

Primer pair 1

Microarray probesets 5

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 7
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:279041 Noda T, et al., Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice. Andrology. 2019;

TSS for Glb1l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88543	Chr9:26717680-26717757 (-)	45 bp
Tssr88542	Chr9:26715781-26715788 (-)	1,979 bp
Tssr88541	Chr9:26715741-26715753 (-)	2,017 bp
Tssr88540	Chr9:26714957-26714964 (-)	2,803 bp
Tssr88539	Chr9:26714925-26714938 (-)	2,832 bp
Tssr88538	Chr9:26713895-26713902 (-)	3,865 bp
Tssr88537	Chr9:26713859-26713886 (-)	3,891 bp
Tssr2812	Chr9:26703296-26703298 (-)	14,467 bp
Tssr88536	Chr9:26703236-26703239 (-)	14,526 bp
Tssr88535	Chr9:26703221-26703224 (-)	14,541 bp
Tssr88534	Chr9:26703187-26703216 (-)	14,562 bp
Tssr88533	Chr9:26703177-26703182 (-)	14,584 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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