Gldn MGI Mouse Gene Detail - MGI:2388361

Symbol

Gldn
Name

gliomedin
Synonyms

CRG-L2, Crlg2

Feature Type

protein coding gene
IDs

MGI:2388361
NCBI Gene: 235379
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:54193770-54249061 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.52 cM
Mapping Data

1 experiment

SNPs within 2kb

1656 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388361	protein coding gene	Chr9:54193770-54249070 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034822	protein coding gene	Chr9:53331232-53382125 (+)
A/J	MGP_AJ_G0034803	protein coding gene	Chr9:51630668-51682295 (+)
AKR/J	MGP_AKRJ_G0034731	protein coding gene	Chr9:52786671-52846047 (+)
BALB/cJ	MGP_BALBcJ_G0034795	protein coding gene	Chr9:51398180-51453663 (+)
C3H/HeJ	MGP_C3HHeJ_G0034505	protein coding gene	Chr9:53263391-53314233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035314	protein coding gene	Chr9:54823008-54873224 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032226	protein coding gene	Chr9:51042222-51093126 (+)
CAST/EiJ	MGP_CASTEiJ_G0033827	protein coding gene	Chr9:53276001-53328499 (+)
CBA/J	MGP_CBAJ_G0034476	protein coding gene	Chr9:56695802-56758165 (+)
DBA/2J	MGP_DBA2J_G0034635	protein coding gene	Chr9:51516786-51572165 (+)
FVB/NJ	MGP_FVBNJ_G0034577	protein coding gene	Chr9:50713978-50765088 (+)
LP/J	MGP_LPJ_G0034717	protein coding gene	Chr9:53635369-53691146 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034620	protein coding gene	Chr9:58275262-58331461 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035336	protein coding gene	Chr9:52790470-52848411 (+)
PWK/PhJ	MGP_PWKPhJ_G0033531	protein coding gene	Chr9:51491277-51542941 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033366	protein coding gene	Chr9:53070217-53123379 (+)
WSB/EiJ	MGP_WSBEiJ_G0033939	protein coding gene	Chr9:52774456-52826005 (+)

Human Ortholog

GLDN, gliomedin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLDN, gliomedin
Synonyms

CLOM, COLM, CRG-L2, CRGL2, LCCS11, UNC-112, UNC-122
Links

HGNC:29514

NCBI Gene ID: 342035

neXtProt AC: NX_Q6ZMI3

UniProt: Q6ZMI3
Chr Location

15q21.2; chr15:51341655-51413365 (+) GRCh38

MGI Vertebrate Homology

Gldn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GLDN
Gene Tree

Gldn

Diseases

1 with human GLDN associations

				Human Disease	Mouse Models
				lethal congenital contracture syndrome IDs lethal congenital contracture syndrome DOID:0060558 ICD10CM:Q68.8 OMIM:PS253310 ORDO:294965

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a knock-out allele fail to form heminodes without overt neurological abnormalities or alteration in nerve conduction.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

12
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gldn

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS23189.1

Ensembl

ENSMUSG00000046167 (Evidence)
NCBI Gene

235379

			Length	Strain/Species	Flank
genomic	235379	NCBI Gene Model \| MGI Sequence Detail	55292	C57BL/6J	± kb
transcript	NM_177350	RefSeq \| MGI Sequence Detail	4649	C57BL/6
polypeptide	Q8BMF8	UniProt \| EBI \| MGI Sequence Detail	549	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008023 gliomedin

(term hierarchy)
PDB

4XAV
InterPro Domains

IPR008160 Collagen triple helix repeat

IPR003112 Olfactomedin-like domain

IPR050605 Olfactomedin-like domain-containing protein
GlyGen

Q8BMF8 6 sites, 1 N-linked glycan (1 site)

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 1

Summaries

All 30

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 7
Earliest

J:86019 Graveel CR, et al., Identification and characterization of CRG-L2, a new marker for liver tumor development. Oncogene. 2003 Mar 20;22(11):1730-6
Latest

J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803

TSS for Gldn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85152	Chr9:54193616-54193627 (+)	-148 bp
Tssr85153	Chr9:54193673-54193682 (+)	-92 bp
Tssr85154	Chr9:54193763-54193778 (+)	1 bp
Tssr85155	Chr9:54236227-54236231 (+)	42,459 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24