Wwc1 MGI Mouse Gene Detail - MGI:2388637 - WW, C2 and coiled-coil domain containing 1

Symbol

Wwc1
Name

WW, C2 and coiled-coil domain containing 1
Synonyms

Kibra, MGC:47054

Feature Type

protein coding gene
IDs

MGI:2388637
NCBI Gene: 211652
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:35729227-35871354 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 21.96 cM
Mapping Data

2 experiments

SNPs within 2kb

4257 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388637	protein coding gene	Chr11:35729226-35871354 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018158	protein coding gene	Chr11:34253117-34401097 (-)
A/J	MGP_AJ_G0018131	protein coding gene	Chr11:32965031-33111134 (-)
AKR/J	MGP_AKRJ_G0018095	protein coding gene	Chr11:33956218-34105889 (-)
BALB/cJ	MGP_BALBcJ_G0018100	protein coding gene	Chr11:33128492-33273291 (-)
C3H/HeJ	MGP_C3HHeJ_G0017913	protein coding gene	Chr11:33917455-34067212 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018554	protein coding gene	Chr11:35289832-35441180 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016209	protein coding gene	Chr11:31418773-31560458 (-)
CAST/EiJ	MGP_CASTEiJ_G0017477	protein coding gene	Chr11:33902089-34051363 (-)
CBA/J	MGP_CBAJ_G0017886	protein coding gene	Chr11:36974849-37134126 (-)
DBA/2J	MGP_DBA2J_G0017996	protein coding gene	Chr11:32708677-32852004 (-)
FVB/NJ	MGP_FVBNJ_G0017990	protein coding gene	Chr11:32560316-32706628 (-)
LP/J	MGP_LPJ_G0018068	protein coding gene	Chr11:34459790-34617447 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018014	protein coding gene	Chr11:37703604-37851387 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018593	protein coding gene	Chr11:33982373-34129100 (-)
PWK/PhJ	MGP_PWKPhJ_G0017258	protein coding gene	Chr11:32796777-32940936 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017050	protein coding gene	Chr11:33750684-33903928 (-)
WSB/EiJ	MGP_WSBEiJ_G0017526	protein coding gene	Chr11:33754851-33906169 (-)

Human Ortholog

WWC1, WW and C2 domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WWC1, WW and C2 domain containing 1
Synonyms

HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Links

HGNC:29435

NCBI Gene ID: 23286

neXtProt AC: NX_Q8IX03

UniProt: Q8IX03
Chr Location

5q34; chr5:168291645-168472303 (+) GRCh38

MGI Vertebrate Homology

Wwc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WWC1
Gene Tree

Wwc1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Wwc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired adult synaptic plasticity and fear-based conditioning.

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All GO Annotations

45
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

21
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wwc1

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS24545.1

Ensembl

ENSMUSG00000018849 (Evidence)
NCBI Gene

211652

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018849	Ensembl Gene Model \| MGI Sequence Detail	142128	C57BL/6J	± kb
transcript	ENSMUST00000018993	Ensembl \| MGI Sequence Detail	4531	Not Applicable
polypeptide	ENSMUSP00000018993	Ensembl \| MGI Sequence Detail	1104	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017462 protein WWC1

(term hierarchy)
PDB

6J68, 6J69, 6JJW, 6JJX, 6JJY
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR037771 WWC, C2 domain

IPR051105 WWC/KIBRA Hippo Pathway Regulators

IPR001202 WW domain

IPR036020 WW domain superfamily

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 6

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MGI:2143978, MGI:2144380

Summaries

All 64

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 26
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358167 Nasello C, et al., Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2307156121

TSS for Wwc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107420	Chr11:35871418-35871435 (-)	-73 bp
Tssr107419	Chr11:35871300-35871406 (-)	1 bp
Tssr107418	Chr11:35871269-35871283 (-)	78 bp
Tssr107417	Chr11:35806420-35806431 (-)	64,928 bp
Tssr107416	Chr11:35806400-35806409 (-)	64,949 bp
Tssr107415	Chr11:35770296-35770301 (-)	101,055 bp
Tssr107414	Chr11:35735228-35735247 (-)	136,116 bp
Tssr107413	Chr11:35733070-35733091 (-)	138,273 bp
Tssr107412	Chr11:35732766-35732818 (-)	138,562 bp
Tssr107411	Chr11:35731277-35731306 (-)	140,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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