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Lrrtm3 Gene Detail
Summary
  • Symbol
    Lrrtm3
  • Name
    leucine rich repeat transmembrane neuronal 3
  • Synonyms
    9630044H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389177
    NCBI Gene: 216028
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63764276-63926034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4530 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389177
 protein coding gene Chr10:63764251-63926056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017320
 protein coding gene Chr10:63472670-63645919 (-)
A/J MGP_AJ_G0017297
 protein coding gene Chr10:61477063-61642576 (-)
AKR/J MGP_AKRJ_G0017258
 protein coding gene Chr10:63127979-63293660 (-)
BALB/cJ MGP_BALBcJ_G0017257
 protein coding gene Chr10:61584461-61745971 (-)
C3H/HeJ MGP_C3HHeJ_G0017081
 protein coding gene Chr10:63044100-63214675 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017715
 protein coding gene Chr10:65766234-65943862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015405
 protein coding gene Chr10:58352609-58510363 (-)
CAST/EiJ MGP_CASTEiJ_G0016651
 protein coding gene Chr10:63111587-63286103 (-)
CBA/J MGP_CBAJ_G0017053
 protein coding gene Chr10:68287389-68467791 (-)
DBA/2J MGP_DBA2J_G0017158
 protein coding gene Chr10:60751023-60917127 (-)
FVB/NJ MGP_FVBNJ_G0017151
 protein coding gene Chr10:60016408-60180075 (-)
LP/J MGP_LPJ_G0017231
 protein coding gene Chr10:63889133-64063232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017179
 protein coding gene Chr10:70365184-70544093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017754
 protein coding gene Chr10:62973944-63142200 (-)
PWK/PhJ MGP_PWKPhJ_G0016435
 protein coding gene Chr10:60618866-60789112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016217
 protein coding gene Chr10:62273419-62444926 (-)
WSB/EiJ MGP_WSBEiJ_G0016715
 protein coding gene Chr10:62902769-63074174 (-)



Homology
more
  • Human Ortholog
    LRRTM3, leucine rich repeat transmembrane neuronal 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRTM3, leucine rich repeat transmembrane neuronal 3
  • Links
    NCBI Gene ID: 347731
    neXtProt AC: NX_Q86VH5
    UniProt: Q86VH5

  • Chr Location
    10q21.3; chr10:66926036-67101551 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced excitatory synapse development with reduced excitatory synapse density, mESPC amplitude, and abnormal synaptic depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    97
  • cDNA Data
    21
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216028 NCBI Gene Model | MGI Sequence Detail 161759 C57BL/6J ±  kb
    transcript NM_178678 RefSeq | MGI Sequence Detail 3852 C57BL/6  
    polypeptide Q8BZ81 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009948 leucine-rich repeat transmembrane neuronal protein 3
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
    • GlyGen
      Q8BZ81 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2445018
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:320789 Kim J, et al., LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2110196119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory