About   Help   FAQ
Maml3 Gene Detail
Summary
  • Symbol
    Maml3
  • Name
    mastermind like transcriptional coactivator 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389461
    NCBI Gene: 433586
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:51595032-52012740 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 22.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11691 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389461
 protein coding gene Chr3:51593328-52012740 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027201
 protein coding gene Chr3:50169490-50611784 (-)
A/J MGP_AJ_G0027161
 protein coding gene Chr3:48701981-49129025 (-)
AKR/J MGP_AKRJ_G0027130
 protein coding gene Chr3:49669526-50097904 (-)
BALB/cJ MGP_BALBcJ_G0027173
 protein coding gene Chr3:48561853-48982233 (-)
C3H/HeJ MGP_C3HHeJ_G0026916
 protein coding gene Chr3:49897840-50328122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027619
 protein coding gene Chr3:52191569-52632953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024979
 protein coding gene Chr3:45329552-45746779 (-)
CAST/EiJ MGP_CASTEiJ_G0026369
 protein coding gene Chr3:49962660-50403727 (-)
CBA/J MGP_CBAJ_G0026893
 protein coding gene Chr3:53812209-54281174 (-)
DBA/2J MGP_DBA2J_G0027027
 protein coding gene Chr3:48306567-48725871 (-)
FVB/NJ MGP_FVBNJ_G0026995
 protein coding gene Chr3:47288245-47708186 (-)
LP/J MGP_LPJ_G0027139
 protein coding gene Chr3:50925703-51367953 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027013
 protein coding gene Chr3:57994695-58440231 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027678
 protein coding gene Chr3:49596560-50029486 (-)
PWK/PhJ MGP_PWKPhJ_G0026101
 protein coding gene Chr3:47959631-48389043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025914
 protein coding gene Chr3:49251921-49670766 (-)
WSB/EiJ MGP_WSBEiJ_G0026443
 protein coding gene Chr3:49703361-50131797 (-)



Homology
more
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
  • Synonyms
    CAGH3, ERDA3, GDN, MAM-2, MAM2, mam-3, TNRC3
  • Links
    NCBI Gene ID: 55534
    neXtProt AC: NX_Q96JK9
    UniProt: Q96JK9

  • Chr Location
    4q31.1; chr4:139716753-140154184 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    39
  • cDNA Data
    10
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 433586 NCBI Gene Model | MGI Sequence Detail 417709 C57BL/6J ±  kb
transcript NM_001004176 RefSeq | MGI Sequence Detail 6499 C57BL/6  
polypeptide NP_001004176 RefSeq | MGI Sequence Detail 1135 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR046369 Mastermind-like 1-3
    IPR048456 Mastermind-like 1/3, transactivation domain 1
    IPR048455 Mastermind-like 1/3, transactivation domain 2
    IPR019082 Neurogenic mastermind-like, N-terminal
    IPR046370 Neurogenic mastermind-like, N-terminal domain superfamily
  • GlyGen
    D4QGC2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2139941, MGI:3055089
References
more
  • Summaries
    All 38
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory