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Tbx22 Gene Detail
Summary
  • Symbol
    Tbx22
  • Name
    T-box 22
  • Synonyms
    D230020M15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389465
    NCBI Gene: 245572
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:106711570-106732584 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389465
 protein coding gene ChrX:106711570-106732586 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036015
 protein coding gene ChrX:104515675-104536646 (+)
A/J MGP_AJ_G0035994
 protein coding gene ChrX:104329679-104350693 (+)
AKR/J MGP_AKRJ_G0035913
 protein coding gene ChrX:107625410-107646434 (+)
BALB/cJ MGP_BALBcJ_G0035985
 protein coding gene ChrX:103091683-103112647 (+)
C3H/HeJ MGP_C3HHeJ_G0035691
 protein coding gene ChrX:104983889-105005887 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036511
 protein coding gene ChrX:107544737-107567578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033339
 protein coding gene ChrX:101581689-101603145 (+)
CAST/EiJ MGP_CASTEiJ_G0034978
 protein coding gene ChrX:89058936-89084906 (+)
CBA/J MGP_CBAJ_G0035667
 protein coding gene ChrX:110920351-110941237 (+)
DBA/2J MGP_DBA2J_G0035821
 protein coding gene ChrX:103565610-103586551 (+)
FVB/NJ MGP_FVBNJ_G0035761
 protein coding gene ChrX:102918977-102940255 (+)
LP/J MGP_LPJ_G0035913
 protein coding gene ChrX:105468953-105494325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035792
 protein coding gene ChrX:115734301-115758587 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036538
 protein coding gene ChrX:104055099-104077223 (+)
PWK/PhJ MGP_PWKPhJ_G0034674
 protein coding gene ChrX:86583973-86605878 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034503
 protein coding gene ChrX:89852848-89881931 (+)
WSB/EiJ MGP_WSBEiJ_G0035116
 protein coding gene ChrX:102836773-102859704 (+)



Homology
more
  • Human Ortholog
    TBX22, T-box transcription factor 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBX22, T-box transcription factor 22
  • Synonyms
    ABERS, CLPA, CPX, dJ795G23.1, TBXX
  • Links
    NCBI Gene ID: 50945
    neXtProt AC: NX_Q9Y458
    UniProt: Q9Y458

  • Chr Location
    Xq21.1; chrX:80014753-80031774 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tbx22 mouse models; 3 with human TBX22 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Half of homozygous female and hemizygous male null mice die neonatally due to breathing or feeding deficits, and show reduced bone formation in the posterior hard palate leading to submucous cleft palate, ankyloglossia, persistent oro-nasal membranes andoccasional overt clefts and choanal atresia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    159
  • cDNA Data
    12
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031241 Ensembl Gene Model | MGI Sequence Detail 21015 C57BL/6J ±  kb
    transcript ENSMUST00000168174 Ensembl | MGI Sequence Detail 5217 Not Applicable  
    polypeptide ENSMUSP00000128247 Ensembl | MGI Sequence Detail 531 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 12
      Primer pair 6
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444683
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:79619 Braybrook C, et al., Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Hum Mol Genet. 2002 Oct 15;11(22):2793-804
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory