About   Help   FAQ
Brcc3 Gene Detail
Summary
  • Symbol
    Brcc3
  • Name
    BRCA1/BRCA2-containing complex, subunit 3
  • Synonyms
    C6.1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389572
    NCBI Gene: 210766
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74460234-74497607 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389572
 protein coding gene ChrX:74460234-74499307 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035860
 protein coding gene ChrX:71260744-71298300 (+)
A/J MGP_AJ_G0035847
 protein coding gene ChrX:71481509-71522309 (+)
AKR/J MGP_AKRJ_G0035768
 protein coding gene ChrX:73335699-73372387 (+)
BALB/cJ MGP_BALBcJ_G0035829
 protein coding gene ChrX:70473761-70514725 (+)
C3H/HeJ MGP_C3HHeJ_G0035539
 protein coding gene ChrX:71760062-71803717 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036359
 protein coding gene ChrX:73540008-73590610 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033198
 protein coding gene ChrX:70992330-71030204 (+)
CAST/EiJ MGP_CASTEiJ_G0034825
 protein coding gene ChrX:57090682-57125337 (+)
CBA/J MGP_CBAJ_G0035512
 protein coding gene ChrX:75505123-75545493 (+)
DBA/2J MGP_DBA2J_G0035670
 protein coding gene ChrX:70934752-70974506 (+)
FVB/NJ MGP_FVBNJ_G0035611
 protein coding gene ChrX:70260211-70301198 (+)
LP/J MGP_LPJ_G0035752
 protein coding gene ChrX:72062398-72099296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035645
 protein coding gene ChrX:78119280-78156135 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036385
 protein coding gene ChrX:71128725-71172935 (+)
PWK/PhJ MGP_PWKPhJ_G0034522
 protein coding gene ChrX:55094141-55130061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034358
 protein coding gene ChrX:57891136-57935807 (+)
WSB/EiJ MGP_WSBEiJ_G0034964
 protein coding gene ChrX:70333835-70374414 (+)



Homology
more
  • Human Ortholog
    BRCC3, BRCA1/BRCA2-containing complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRCC3, BRCA1/BRCA2-containing complex subunit 3
  • Synonyms
    BRCC36, C6.1A, CXorf53
  • Links
    NCBI Gene ID: 79184
    neXtProt AC: NX_P46736
    UniProt: P46736

  • Chr Location
    Xq28; chrX:155071420-155123077 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced lethality in response to LPS treatment, decreased induced secretion of IL18 and IL1b, and impaired recruitment of neutrophils and monocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    13
  • cDNA Data
    57
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031201 Ensembl Gene Model | MGI Sequence Detail 37374 C57BL/6J ±  kb
transcript ENSMUST00000033544 Ensembl | MGI Sequence Detail 4310 Not Applicable  
polypeptide ENSMUSP00000033544 Ensembl | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 8
References
more
  • Summaries
    All 58
    Developmental Gene Expression 3
    Gene Ontology 15
    Phenotypes 13
  • Earliest
    J:57583 Fisch P, et al., The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another. Oncogene. 1993 Dec;8(12):3271-6
  • Latest
    J:347867 Huang X, et al., BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome. CNS Neurosci Ther. 2024 Mar;30(3):e14697
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory