Irak2 MGI Mouse Gene Detail - MGI:2429603 - interleukin-1 receptor-associated kinase 2

Symbol

Irak2
Name

interleukin-1 receptor-associated kinase 2
Synonyms

6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d

Feature Type

protein coding gene
IDs

MGI:2429603
NCBI Gene: 108960
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr6:113615428-113671987 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.82 cM
Mapping Data

4 experiments

SNPs within 2kb

1636 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2429603	protein coding gene	Chr6:113615428-113671987 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031134	protein coding gene	Chr6:116177572-116239750 (+)
A/J	MGP_AJ_G0031103	protein coding gene	Chr6:111717395-111775226 (+)
AKR/J	MGP_AKRJ_G0031034	protein coding gene	Chr6:114718203-114779949 (+)
BALB/cJ	MGP_BALBcJ_G0031114	protein coding gene	Chr6:111663189-111720623 (+)
C3H/HeJ	MGP_C3HHeJ_G0030594	protein coding gene	Chr6:69517467-69580646 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031573	protein coding gene	Chr6:119169388-119236237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028737	protein coding gene	Chr6:108743266-108800840 (+)
CAST/EiJ	MGP_CASTEiJ_G0030221	protein coding gene	Chr6:115176299-115237443 (+)
CBA/J	MGP_CBAJ_G0030800	protein coding gene	Chr6:123881510-123946141 (+)
DBA/2J	MGP_DBA2J_G0030953	protein coding gene	Chr6:110798915-110855542 (+)
FVB/NJ	MGP_FVBNJ_G0030907	protein coding gene	Chr6:109802279-109859729 (+)
LP/J	MGP_LPJ_G0031033	protein coding gene	Chr6:116202661-116264060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030941	protein coding gene	Chr6:128134885-128194291 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031600	protein coding gene	Chr6:114735117-114798381 (+)
PWK/PhJ	MGP_PWKPhJ_G0029937	protein coding gene	Chr6:109753252-109817351 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029765	protein coding gene	Chr6:113543535-113604449 (+)
WSB/EiJ	MGP_WSBEiJ_G0030305	protein coding gene	Chr6:115113281-115174313 (+)

Human Ortholog

IRAK2, interleukin 1 receptor associated kinase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRAK2, interleukin 1 receptor associated kinase 2
Synonyms

IRAK-2
Links

HGNC:6113

NCBI Gene ID: 3656

neXtProt AC: NX_O43187

UniProt: O43187
Chr Location

3p25.3; chr3:10164919-10243745 (+) GRCh38

MGI Vertebrate Homology

Irak2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IRAK2
Gene Tree

Irak2

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Phenotype Summary

12 phenotypes from 4 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

3
Gene trapped

21
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Irak2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

24
cDNA Data

24
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irak2

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All Sequences

59
RefSeq

6
UniProt

2
CCDS

CCDS20430.1, CCDS51873.1

Ensembl

ENSMUSG00000060477 (Evidence)
NCBI Gene

108960

			Length	Strain/Species	Flank
genomic	108960	NCBI Gene Model \| MGI Sequence Detail	56560	C57BL/6J	± kb
transcript	NM_172161	RefSeq \| MGI Sequence Detail	3209	ZRU/MplStud
polypeptide	Q8CFA1	UniProt \| EBI \| MGI Sequence Detail	622	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001783 interleukin-1 receptor-associated kinase-like 2

(term hierarchy)
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR042151 IRAK2, death domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 25

cDNA 25

Microarray probesets 3

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MGI:1922037, MGI:2141461

Summaries

All 63

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 26
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347749 Pereira M, et al., The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27;43(2):113795

TSS for Irak2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58237	Chr6:113615444-113615505 (+)	47 bp
Tssr58238	Chr6:113627562-113627564 (+)	12,135 bp
Tssr58239	Chr6:113631331-113631355 (+)	15,915 bp
Tssr58240	Chr6:113637599-113637612 (+)	22,178 bp
Tssr58241	Chr6:113637630-113637651 (+)	22,213 bp
Tssr1960	Chr6:113637656-113637667 (+)	22,234 bp
Tssr58242	Chr6:113637670-113637679 (+)	22,247 bp
Tssr58243	Chr6:113645019-113645058 (+)	29,611 bp
Tssr1961	Chr6:113647052-113647057 (+)	31,627 bp
Tssr1962	Chr6:113647122-113647161 (+)	31,714 bp
Tssr58244	Chr6:113649980-113650012 (+)	34,568 bp
Tssr58245	Chr6:113658872-113658886 (+)	43,451 bp
Tssr58246	Chr6:113659002-113659018 (+)	43,582 bp
Tssr58247	Chr6:113661057-113661077 (+)	45,639 bp
Tssr58248	Chr6:113667683-113667704 (+)	52,266 bp
Tssr58249	Chr6:113667715-113667730 (+)	52,295 bp
Tssr58250	Chr6:113667917-113667937 (+)	52,499 bp
Tssr58251	Chr6:113667947-113667958 (+)	52,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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