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Nlrx1 Gene Detail
Summary
  • Symbol
    Nlrx1
  • Name
    NLR family member X1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429611
    NCBI Gene: 270151
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44164014-44179896 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429611
 protein coding gene Chr9:44164010-44179896 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034697
 protein coding gene Chr9:42725981-42744444 (-)
A/J MGP_AJ_G0034678
 protein coding gene Chr9:41543207-41558517 (-)
AKR/J MGP_AKRJ_G0034604
 protein coding gene Chr9:42404147-42420388 (-)
BALB/cJ MGP_BALBcJ_G0034669
 protein coding gene Chr9:41289310-41304635 (-)
C3H/HeJ MGP_C3HHeJ_G0034380
 protein coding gene Chr9:42853411-42868781 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035190
 protein coding gene Chr9:43996604-44013543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032105
 protein coding gene Chr9:41126443-41140713 (-)
CAST/EiJ MGP_CASTEiJ_G0033702
 protein coding gene Chr9:42693476-42711424 (-)
CBA/J MGP_CBAJ_G0034352
 protein coding gene Chr9:45593168-45611608 (-)
DBA/2J MGP_DBA2J_G0034511
 protein coding gene Chr9:41446581-41463198 (-)
FVB/NJ MGP_FVBNJ_G0034452
 protein coding gene Chr9:40695058-40710571 (-)
LP/J MGP_LPJ_G0034592
 protein coding gene Chr9:43023950-43041657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034496
 protein coding gene Chr9:47449001-47464333 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035211
 protein coding gene Chr9:42300143-42315478 (-)
PWK/PhJ MGP_PWKPhJ_G0033408
 protein coding gene Chr9:41318231-41334386 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033242
 protein coding gene Chr9:42615504-42632407 (-)
WSB/EiJ MGP_WSBEiJ_G0033815
 protein coding gene Chr9:42335854-42351488 (-)



Homology
more
  • Human Ortholog
    NLRX1, NLR family member X1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRX1, NLR family member X1
  • Synonyms
    CLR11.3, DLNB26, NOD26, NOD5, NOD9
  • Links
    NCBI Gene ID: 79671
    neXtProt AC: NX_Q86UT6
    UniProt: Q86UT6

  • Chr Location
    11q23.3; chr11:119166568-119184016 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032109 Ensembl Gene Model | MGI Sequence Detail 15883 C57BL/6J ±  kb
    transcript ENSMUST00000168499 Ensembl | MGI Sequence Detail 3579 Not Applicable  
    polypeptide ENSMUSP00000127531 Ensembl | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011278 NLR family member X1
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR052394 Leucine-rich repeat-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR007111 NACHT nucleoside triphosphatase
      IPR048900 NLR family member X1, C-terminal domain
      IPR051261 NOD-like receptor (NLR)
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q3TL44 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:78123 Kameya S, et al., Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet. 2002 Aug 1;11(16):1879-86
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory