Hrh4 MGI Mouse Gene Detail - MGI:2429635

Symbol

Hrh4
Name

histamine receptor H4
Synonyms

H4R

Feature Type

protein coding gene
IDs

MGI:2429635
NCBI Gene: 225192
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:13140047-13155939 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 6.88 cM
Mapping Data

1 experiment

SNPs within 2kb

613 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2429635	protein coding gene	Chr18:13140039-13156758 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024165	protein coding gene	Chr18:10232245-10252056 (+)
A/J	MGP_AJ_G0024127	protein coding gene	Chr18:10017424-10035919 (+)
AKR/J	MGP_AKRJ_G0024094	protein coding gene	Chr18:10322479-10340847 (+)
BALB/cJ	MGP_BALBcJ_G0024126	protein coding gene	Chr18:9976994-9992810 (+)
C3H/HeJ	MGP_C3HHeJ_G0023893	protein coding gene	Chr18:10208324-10226413 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024571	protein coding gene	Chr18:10730029-10748865 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022011	protein coding gene	Chr18:9588717-9604988 (+)
CAST/EiJ	MGP_CASTEiJ_G0023370	protein coding gene	Chr18:10107641-10125851 (+)
CBA/J	MGP_CBAJ_G0023865	protein coding gene	Chr18:10887407-10905627 (+)
DBA/2J	MGP_DBA2J_G0023994	protein coding gene	Chr18:9852770-9872356 (+)
FVB/NJ	MGP_FVBNJ_G0023959	protein coding gene	Chr18:9727655-9744283 (+)
LP/J	MGP_LPJ_G0024077	protein coding gene	Chr18:10314009-10331179 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023988	protein coding gene	Chr18:11017343-11034193 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024617	protein coding gene	Chr18:10084894-10103382 (+)
PWK/PhJ	MGP_PWKPhJ_G0023116	protein coding gene	Chr18:9939778-9955954 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022925	protein coding gene	Chr18:10372655-10388661 (+)
WSB/EiJ	MGP_WSBEiJ_G0023436	protein coding gene	Chr18:10096264-10111918 (+)

Human Ortholog

HRH4, histamine receptor H4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HRH4, histamine receptor H4
Synonyms

AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
Links

HGNC:17383

NCBI Gene ID: 59340

neXtProt AC: NX_Q9H3N8

UniProt: Q9H3N8
Chr Location

18q11.2; chr18:24460637-24479974 (+) GRCh38

MGI Vertebrate Homology

Hrh4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HRH4
Gene Tree

Hrh4

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased allergic response to airway inflammation and decreased Th2 responses.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

6
UniProt

4
CCDS

CCDS29069.1

Ensembl

ENSMUSG00000037346 (Evidence)
NCBI Gene

225192

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037346	Ensembl Gene Model \| MGI Sequence Detail	15893	C57BL/6J	± kb
transcript	ENSMUST00000041676	Ensembl \| MGI Sequence Detail	1537	Not Applicable
polypeptide	ENSMUSP00000041061	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001565 H4 histamine receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR008102 Histamine H4 receptor
GlyGen

Q91ZY2 2 sites

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All nucleic 3

cDNA 3

Microarray probesets 2

Summaries

All 50

Gene Ontology 5

Phenotypes 28
Earliest

J:79370 Liu C, et al., Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hrh4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150125	Chr18:13139992-13140007 (+)	-47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24