Gbp5 Gene Detail

Summary

• Symbol
  Gbp5
• Name
  guanylate binding protein 5
• Synonyms
  5330409J06Rik, Gbp5a

• Feature Type
  protein coding gene
• IDs
  MGI:2429943
  NCBI Gene: 229898
• Alliance
  gene page
• Transcription Start Sites
  69 TSS

Location &
Maps

• Sequence Map
  Chr3:142202695-142228105 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 66.69 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  820 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2429943	protein coding gene	Chr3:142199739-142228105 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027941	protein coding gene	Chr3:145662510-145704219 (+)
A/J	MGP_AJ_G0027898	protein coding gene	Chr3:140508289-140550491 (+)
AKR/J	MGP_AKRJ_G0027864	protein coding gene	Chr3:144234746-144259592 (+)
BALB/cJ	MGP_BALBcJ_G0027910	protein coding gene	Chr3:140315178-140354743 (+)
C3H/HeJ	MGP_C3HHeJ_G0027640	protein coding gene	Chr3:144566911-144611475 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028354	protein coding gene	Chr3:150743920-150778033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025692	protein coding gene	Chr3:135765885-135787581 (+)
CAST/EiJ	MGP_CASTEiJ_G0027098	protein coding gene	Chr3:144583733-144593238 (-)
CBA/J	MGP_CBAJ_G0027617	protein coding gene	Chr3:155941764-155968041 (+)
DBA/2J	MGP_DBA2J_G0027756	protein coding gene	Chr3:139658810-139681242 (+)
FVB/NJ	MGP_FVBNJ_G0027723	protein coding gene	Chr3:137080661-137102325 (+)
LP/J	MGP_LPJ_G0027866	protein coding gene	Chr3:147101146-147137895 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027755	protein coding gene	Chr3:164259052-164286544 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028412	protein coding gene	Chr3:143845758-143874726 (+)
PWK/PhJ	MGP_PWKPhJ_G0026820	protein coding gene	Chr3:139462379-139493785 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026647	protein coding gene	Chr3:141967553-141998716 (+)
WSB/EiJ	MGP_WSBEiJ_G0027175	protein coding gene	Chr3:144708985-144735126 (+)

Homology

• Human Ortholog
  GBP5, guanylate binding protein 5

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GBP5, guanylate binding protein 5
  
• Synonyms
  GBP-5
• Links
  HGNC:19895

  NCBI Gene ID: 115362

  neXtProt AC: NX_Q96PP8

  UniProt: Q96PP8

  
  
• Chr Location
  1p22.2; chr1:89256189-89272860 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gbp5 stringent orthology
  1 human;1 mouse;1 rat;4 zebrafish
  
• HCOP
  vertebrate homology predictions: GBP5
• Gene Tree
  Gbp5
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 2 alleles in 2 genetic backgrounds
  1 phenotype from multigenic genotypes
  37 phenotype references
  

• All Mutations and Alleles
  15
• Endonuclease-mediated
  9
• Radiation induced
  1
• Targeted
  5
• Genomic Mutations
  2 involving Gbp5
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  39 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased susceptibility to Listeria infection and NLRP3 inflammation.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  52
• GO References
  17

Expression

• Assay Results
  706
• cDNA Data
  18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gbp5

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS17877.1

• Ensembl
  ENSMUSG00000105504 (Evidence)
• NCBI Gene
  229898

Representative Sequences			Length	Strain/Species
genomic	229898	NCBI Gene Model | MGI Sequence Detail	25411	C57BL/6J
transcript	NM_153564	RefSeq | MGI Sequence Detail	3021	C57BL/6
polypeptide	Q8CFB4	UniProt | EBI | MGI Sequence Detail	590	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000007878 guanylate-binding protein 5
  (term hierarchy)
• EC
  3.6.5.-
• InterPro Domains
  IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
  IPR003191 Guanylate-binding protein/Atlastin, C-terminal
  IPR037684 Guanylate-binding protein, C-terminal
  IPR036543 Guanylate-binding protein, C-terminal domain superfamily
  IPR015894 Guanylate-binding protein, N-terminal
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• All nucleic 18

  cDNA 18

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:2444553

References

• Summaries
  All 70

  Diseases 1

  Gene Ontology 17

  Phenotypes 37
• Earliest
  J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• Latest
  J:350745 Marinho FV, et al., Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection. Front Immunol. 2024;15:1341464

TSS for Gbp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32047	Chr3:142202533-142202550 (+)	-153 bp
Tssr32048	Chr3:142202552-142202565 (+)	-136 bp
Tssr32049	Chr3:142202576-142202591 (+)	-111 bp
Tssr32050	Chr3:142202634-142202653 (+)	-51 bp
Tssr32051	Chr3:142202685-142202700 (+)	-2 bp
Tssr32052	Chr3:142206308-142206315 (+)	3,617 bp
Tssr32053	Chr3:142206358-142206367 (+)	3,668 bp
Tssr32054	Chr3:142206368-142206380 (+)	3,679 bp
Tssr32055	Chr3:142206381-142206393 (+)	3,692 bp
Tssr32056	Chr3:142206430-142206456 (+)	3,748 bp
Tssr32057	Chr3:142207013-142207037 (+)	4,330 bp
Tssr32058	Chr3:142207059-142207101 (+)	4,385 bp
Tssr32059	Chr3:142207145-142207157 (+)	4,456 bp
Tssr32060	Chr3:142207350-142207372 (+)	4,666 bp
Tssr32061	Chr3:142207434-142207442 (+)	4,743 bp
Tssr32062	Chr3:142208789-142208842 (+)	6,121 bp
Tssr32063	Chr3:142208864-142208874 (+)	6,174 bp
Tssr32064	Chr3:142209145-142209156 (+)	6,456 bp
Tssr32065	Chr3:142209605-142209637 (+)	6,926 bp
Tssr32066	Chr3:142210107-142210136 (+)	7,427 bp
Tssr32067	Chr3:142210589-142210599 (+)	7,899 bp
Tssr32068	Chr3:142211184-142211195 (+)	8,495 bp
Tssr32069	Chr3:142211230-142211240 (+)	8,540 bp
Tssr32070	Chr3:142211256-142211265 (+)	8,566 bp
Tssr32071	Chr3:142211284-142211295 (+)	8,595 bp
Tssr32072	Chr3:142211318-142211333 (+)	8,631 bp
Tssr32073	Chr3:142211348-142211365 (+)	8,662 bp
Tssr32074	Chr3:142211393-142211405 (+)	8,704 bp
Tssr32075	Chr3:142211417-142211432 (+)	8,730 bp
Tssr32076	Chr3:142211453-142211475 (+)	8,769 bp
Tssr32077	Chr3:142211517-142211526 (+)	8,827 bp
Tssr32078	Chr3:142211552-142211571 (+)	8,867 bp
Tssr32079	Chr3:142211578-142211585 (+)	8,887 bp
Tssr32080	Chr3:142212409-142212413 (+)	9,716 bp
Tssr32081	Chr3:142212487-142212494 (+)	9,796 bp
Tssr32082	Chr3:142212505-142212519 (+)	9,817 bp
Tssr32083	Chr3:142212540-142212561 (+)	9,856 bp
Tssr32084	Chr3:142212577-142212593 (+)	9,890 bp
Tssr32085	Chr3:142212599-142212613 (+)	9,911 bp
Tssr32086	Chr3:142212638-142212650 (+)	9,949 bp
Tssr32087	Chr3:142213437-142213470 (+)	10,759 bp
Tssr32088	Chr3:142213473-142213488 (+)	10,786 bp
Tssr32089	Chr3:142213493-142213507 (+)	10,805 bp
Tssr32090	Chr3:142213677-142213682 (+)	10,985 bp
Tssr32091	Chr3:142213685-142213710 (+)	11,003 bp
Tssr32092	Chr3:142213714-142213732 (+)	11,028 bp
Tssr32093	Chr3:142213805-142213817 (+)	11,116 bp
Tssr32094	Chr3:142213994-142214008 (+)	11,306 bp
Tssr32095	Chr3:142215643-142215652 (+)	12,953 bp
Tssr32096	Chr3:142215952-142215985 (+)	13,274 bp
Tssr32097	Chr3:142216495-142216504 (+)	13,805 bp
Tssr32098	Chr3:142216782-142216791 (+)	14,092 bp
Tssr32099	Chr3:142217310-142217353 (+)	14,637 bp
Tssr32100	Chr3:142217822-142217852 (+)	15,142 bp
Tssr32101	Chr3:142217886-142217898 (+)	15,197 bp
Tssr32102	Chr3:142217947-142217961 (+)	15,259 bp
Tssr32103	Chr3:142224927-142224938 (+)	22,238 bp
Tssr32104	Chr3:142225041-142225052 (+)	22,352 bp
Tssr32105	Chr3:142225082-142225094 (+)	22,393 bp
Tssr32106	Chr3:142225106-142225122 (+)	22,419 bp
Tssr32107	Chr3:142225169-142225201 (+)	22,490 bp
Tssr32108	Chr3:142225261-142225277 (+)	22,574 bp
Tssr32109	Chr3:142225877-142225880 (+)	23,184 bp
Tssr32110	Chr3:142226398-142226413 (+)	23,711 bp
Tssr32111	Chr3:142227076-142227091 (+)	24,389 bp
Tssr32112	Chr3:142227344-142227364 (+)	24,659 bp
Tssr32113	Chr3:142227397-142227408 (+)	24,708 bp
Tssr32114	Chr3:142227491-142227504 (+)	24,803 bp
Tssr32115	Chr3:142228023-142228034 (+)	25,334 bp