Pbxip1 MGI Mouse Gene Detail - MGI:2441670 - pre B cell leukemia transcription factor interacting protein 1

Symbol

Pbxip1
Name

pre B cell leukemia transcription factor interacting protein 1
Synonyms

4732463H20Rik

Feature Type

protein coding gene
IDs

MGI:2441670
NCBI Gene: 229534
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:89344013-89358259 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.12 cM
Mapping Data

1 experiment

SNPs within 2kb

407 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441670	protein coding gene	Chr3:89343982-89358259 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027441	protein coding gene	Chr3:89652651-89666897 (+)
A/J	MGP_AJ_G0027405	protein coding gene	Chr3:86685652-86700212 (+)
AKR/J	MGP_AKRJ_G0027369	protein coding gene	Chr3:88784491-88798729 (+)
BALB/cJ	MGP_BALBcJ_G0027414	protein coding gene	Chr3:86654253-86668498 (+)
C3H/HeJ	MGP_C3HHeJ_G0027156	protein coding gene	Chr3:88986836-89002644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027860	protein coding gene	Chr3:93037324-93051552 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025212	protein coding gene	Chr3:82169353-82183417 (+)
CAST/EiJ	MGP_CASTEiJ_G0026602	protein coding gene	Chr3:89345284-89360708 (+)
CBA/J	MGP_CBAJ_G0027130	protein coding gene	Chr3:96231168-96245411 (+)
DBA/2J	MGP_DBA2J_G0027268	protein coding gene	Chr3:86063579-86077831 (+)
FVB/NJ	MGP_FVBNJ_G0027236	protein coding gene	Chr3:84404263-84419774 (+)
LP/J	MGP_LPJ_G0027377	protein coding gene	Chr3:90732122-90746369 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027256	protein coding gene	Chr3:102437057-102452809 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027919	protein coding gene	Chr3:88539357-88554448 (+)
PWK/PhJ	MGP_PWKPhJ_G0026336	protein coding gene	Chr3:85941348-85955946 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026155	protein coding gene	Chr3:87717882-87732149 (+)
WSB/EiJ	MGP_WSBEiJ_G0026684	protein coding gene	Chr3:88936178-88950410 (+)

Human Ortholog

PBXIP1, PBX homeobox interacting protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PBXIP1, PBX homeobox interacting protein 1
Synonyms

HPIP
Links

HGNC:21199

NCBI Gene ID: 57326

neXtProt AC: NX_Q96AQ6

UniProt: Q96AQ6
Chr Location

1q21.3; chr1:154944076-154956123 (-) GRCh38

MGI Vertebrate Homology

Pbxip1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PBXIP1
Gene Tree

Pbxip1

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Pbxip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit proportional dwafism. Mice homozygous for a conditional allele activated in chondrocytes exhibit improved induced pathogenic osteoarthritis.

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All GO Annotations

45
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

19
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pbxip1a, pbxip1b

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All Sequences

68
RefSeq

8
UniProt

4
CCDS

CCDS17510.1

Ensembl

ENSMUSG00000042613 (Evidence)
NCBI Gene

229534

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042613	Ensembl Gene Model \| MGI Sequence Detail	14247	C57BL/6J	± kb
transcript	ENSMUST00000038942	Ensembl \| MGI Sequence Detail	4479	Not Applicable
polypeptide	ENSMUSP00000040429	Ensembl \| MGI Sequence Detail	727	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012330 pre-B-cell leukemia transcription factor-interacting protein 1

(term hierarchy)
InterPro Domains

IPR051990 Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting
GlyGen

Q3TVI8 2 sites, 6 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 19

Other 1

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 11
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Pbxip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30117	Chr3:89344006-89344041 (+)	11 bp
Tssr30118	Chr3:89344043-89344068 (+)	43 bp
Tssr30119	Chr3:89344186-89344199 (+)	180 bp
Tssr942	Chr3:89344838-89344880 (+)	846 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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