Gpr158 MGI Mouse Gene Detail - MGI:2441697 - G protein-coupled receptor 158

Symbol

Gpr158
Name

G protein-coupled receptor 158
Synonyms

5330427M13Rik, mKIAA1136

Feature Type

protein coding gene
IDs

MGI:2441697
NCBI Gene: 241263
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:21372378-21835355 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 14.92 cM
Mapping Data

2 experiments

SNPs within 2kb

15112 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441697	protein coding gene	Chr2:21372353-21835358 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025389	protein coding gene	Chr2:19187739-19668114 (+)
A/J	MGP_AJ_G0025367	protein coding gene	Chr2:18408338-18872089 (+)
AKR/J	MGP_AKRJ_G0025335	protein coding gene	Chr2:19083694-19532741 (+)
BALB/cJ	MGP_BALBcJ_G0025362	protein coding gene	Chr2:18471628-18937119 (+)
C3H/HeJ	MGP_C3HHeJ_G0025122	protein coding gene	Chr2:18944351-19419858 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025805	protein coding gene	Chr2:19722086-20216173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023220	protein coding gene	Chr2:17671624-18063234 (+)
CAST/EiJ	MGP_CASTEiJ_G0024586	protein coding gene	Chr2:18895408-19394040 (+)
CBA/J	MGP_CBAJ_G0025101	protein coding gene	Chr2:20519129-20996790 (+)
DBA/2J	MGP_DBA2J_G0025233	protein coding gene	Chr2:18325679-18796887 (+)
FVB/NJ	MGP_FVBNJ_G0025196	protein coding gene	Chr2:18109566-18569454 (+)
LP/J	MGP_LPJ_G0025320	protein coding gene	Chr2:19029017-19491551 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025227	protein coding gene	Chr2:20454773-20992685 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025863	protein coding gene	Chr2:18957282-19410516 (+)
PWK/PhJ	MGP_PWKPhJ_G0024335	protein coding gene	Chr2:18181652-18613790 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024135	protein coding gene	Chr2:19172541-19619693 (+)
WSB/EiJ	MGP_WSBEiJ_G0024656	protein coding gene	Chr2:19037681-19492148 (+)

Human Ortholog

GPR158, G protein-coupled receptor 158

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR158, G protein-coupled receptor 158
Synonyms

mGlyR
Links

HGNC:23689

NCBI Gene ID: 57512

neXtProt AC: NX_Q5T848

UniProt: Q5T848
Chr Location

10p12.1; chr10:25174802-25602229 (+) GRCh38

MGI Vertebrate Homology

Gpr158 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPR158
Gene Tree

Gpr158

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

75 strains or lines available

Mice homozygous for a knock-out allele exhibit antidepressant-like behaviors, reduced anxiety-related response and elevated AMPAR-signalling.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

44
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr158

ZFIN gpr158a

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All Sequences

35
RefSeq

3
UniProt

3
CCDS

CCDS15722.1, CCDS15723.1

Ensembl

ENSMUSG00000045967 (Evidence)
NCBI Gene

241263

			Length	Strain/Species	Flank
genomic	241263	NCBI Gene Model \| MGI Sequence Detail	462978	C57BL/6J	± kb
transcript	NM_001004761	RefSeq \| MGI Sequence Detail	7143	C57BL/6
polypeptide	Q8C419	UniProt \| EBI \| MGI Sequence Detail	1200	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030349 metabotropic glycine receptor

(term hierarchy)
InterPro Domains

IPR017978 GPCR family 3, C-terminal

IPR043458 G-protein coupled receptor 158/179
GlyGen

Q8C419 8 sites, 11 N-linked glycans (6 sites), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 12

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 20
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpr158:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16468	Chr2:21372343-21372351 (+)	-31 bp
Tssr16469	Chr2:21372358-21372359 (+)	-19 bp
Tssr16470	Chr2:21372378-21372407 (+)	15 bp
Tssr16471	Chr2:21372409-21372428 (+)	41 bp
Tssr16472	Chr2:21372632-21372681 (+)	279 bp
Tssr421	Chr2:21506674-21506682 (+)	134,300 bp
Tssr16473	Chr2:21513894-21513896 (+)	141,517 bp
Tssr16474	Chr2:21655247-21655250 (+)	282,871 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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