Traf3ip3 MGI Mouse Gene Detail - MGI:2441706 - TRAF3 interacting protein 3

Symbol

Traf3ip3
Name

TRAF3 interacting protein 3
Synonyms

6030423D04Rik

Feature Type

protein coding gene
IDs

MGI:2441706
NCBI Gene: 215243
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:192857812-192883854 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 97.62 cM
Mapping Data

2 experiments

SNPs within 2kb

753 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441706	protein coding gene	Chr1:192857761-192884011 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016960	protein coding gene	Chr1:200264220-200290464 (-)
A/J	MGP_AJ_G0016939	protein coding gene	Chr1:192025197-192051445 (-)
AKR/J	MGP_AKRJ_G0016904	protein coding gene	Chr1:197752193-197778444 (-)
BALB/cJ	MGP_BALBcJ_G0016897	protein coding gene	Chr1:192721945-192748188 (-)
C3H/HeJ	MGP_C3HHeJ_G0016721	protein coding gene	Chr1:198588712-198620335 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017360	protein coding gene	Chr1:206629542-206655790 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015067	protein coding gene	Chr1:182900574-182927710 (-)
CAST/EiJ	MGP_CASTEiJ_G0016304	protein coding gene	Chr1:198172031-198200452 (-)
CBA/J	MGP_CBAJ_G0016695	protein coding gene	Chr1:214263573-214289806 (-)
DBA/2J	MGP_DBA2J_G0016801	protein coding gene	Chr1:190743664-190769871 (-)
FVB/NJ	MGP_FVBNJ_G0016797	protein coding gene	Chr1:188868042-188894397 (-)
LP/J	MGP_LPJ_G0016876	protein coding gene	Chr1:201441566-201468594 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016829	protein coding gene	Chr1:220899214-220925542 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017397	protein coding gene	Chr1:197570675-197596890 (-)
PWK/PhJ	MGP_PWKPhJ_G0016091	protein coding gene	Chr1:190065312-190091726 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015867	protein coding gene	Chr1:196599690-196625958 (-)
WSB/EiJ	MGP_WSBEiJ_G0016366	protein coding gene	Chr1:197859887-197886448 (-)

Human Ortholog

TRAF3IP3, TRAF3 interacting protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAF3IP3, TRAF3 interacting protein 3
Synonyms

T3JAM
Links

HGNC:30766

NCBI Gene ID: 80342

neXtProt AC: NX_Q9Y228

UniProt: Q9Y228
Chr Location

1q32.2; chr1:209756032-209782320 (+) GRCh38

MGI Vertebrate Homology

Traf3ip3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TRAF3IP3
Gene Tree

Traf3ip3

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired single positive thymocyte development and increased gamma-delta T cell numbers.

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All GO Annotations

20
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

14
cDNA Data

34
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase traf3ip3

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All Sequences

60
RefSeq

2
UniProt

8
CCDS

CCDS15634.1

Ensembl

ENSMUSG00000037318 (Evidence)
NCBI Gene

215243

			Length	Strain/Species	Flank
genomic	215243	NCBI Gene Model \| MGI Sequence Detail	26043	C57BL/6J	± kb
transcript	NM_153137	RefSeq \| MGI Sequence Detail	2142	C57BL/6
polypeptide	Q8C0G2	UniProt \| EBI \| MGI Sequence Detail	513	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016603 TRAF3-interacting JNK-activating modulator

(term hierarchy)
InterPro Domains

IPR051176 Centrosomal and Immune Signaling Modulators

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All nucleic 38

cDNA 38

Microarray probesets 4

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MGI:2138156

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Traf3ip3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15847	Chr1:192883905-192883916 (-)	-57 bp
Tssr15846	Chr1:192883743-192883892 (-)	36 bp
Tssr15845	Chr1:192883702-192883725 (-)	140 bp
Tssr15844	Chr1:192883445-192883466 (-)	398 bp
Tssr15843	Chr1:192880258-192880339 (-)	3,555 bp
Tssr15842	Chr1:192880201-192880214 (-)	3,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24