Sctr MGI Mouse Gene Detail - MGI:2441720

Symbol

Sctr
Name

secretin receptor
Synonyms

6530402O03Rik

Feature Type

protein coding gene
IDs

MGI:2441720
NCBI Gene: 319229
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:119934710-119991269 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.57 cM
Mapping Data

1 experiment

SNPs within 2kb

1637 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441720	protein coding gene	Chr1:119934624-119991269 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016401	protein coding gene	Chr1:122777496-122844975 (+)
A/J	MGP_AJ_G0016384	protein coding gene	Chr1:118380952-118437685 (+)
AKR/J	MGP_AKRJ_G0016349	protein coding gene	Chr1:121865550-121923292 (+)
BALB/cJ	MGP_BALBcJ_G0016344	protein coding gene	Chr1:118644148-118702776 (+)
C3H/HeJ	MGP_C3HHeJ_G0016170	protein coding gene	Chr1:122034455-122097477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016805	protein coding gene	Chr1:127461579-127524408 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014518	protein coding gene	Chr1:112036176-112087723 (+)
CAST/EiJ	MGP_CASTEiJ_G0015751	protein coding gene	Chr1:120824290-120888801 (+)
CBA/J	MGP_CBAJ_G0016143	protein coding gene	Chr1:131872839-131942122 (+)
DBA/2J	MGP_DBA2J_G0016249	protein coding gene	Chr1:117404020-117464359 (+)
FVB/NJ	MGP_FVBNJ_G0016248	protein coding gene	Chr1:116154394-116212783 (+)
LP/J	MGP_LPJ_G0016320	protein coding gene	Chr1:124129019-124194800 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016273	protein coding gene	Chr1:137612187-137688713 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016841	protein coding gene	Chr1:121592614-121654182 (+)
PWK/PhJ	MGP_PWKPhJ_G0015537	protein coding gene	Chr1:116383199-116442727 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015325	protein coding gene	Chr1:120478197-120538401 (+)
WSB/EiJ	MGP_WSBEiJ_G0015813	protein coding gene	Chr1:121465789-121527265 (+)

Human Ortholog

SCTR, secretin receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCTR, secretin receptor
Synonyms

SR
Links

HGNC:10608

NCBI Gene ID: 6344

neXtProt AC: NX_P47872

UniProt: P47872
Chr Location

2q14.2; chr2:119439843-119525301 (-) GRCh38

MGI Vertebrate Homology

Sctr stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SCTR
Gene Tree

Sctr

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References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Sctr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show polydipsia, polyuria, decreased urine osmolality, higher serum glucose levels, kidney glomerular and tubular pathology, and impaired renal water reabsorption. Homozygotes for a different null allele show impaired synaptic plasticity and social behavior.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

29
UniProt

2
CCDS

CCDS48341.1, CCDS78668.1

Ensembl

ENSMUSG00000026387 (Evidence)
NCBI Gene

319229

			Length	Strain/Species	Flank
genomic	319229	NCBI Gene Model \| MGI Sequence Detail	56560	C57BL/6J	± kb
transcript	NM_001012322	RefSeq \| MGI Sequence Detail	1939	C57BL/6
polypeptide	Q5FWI2	UniProt \| EBI \| MGI Sequence Detail	447	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014544 secretin receptor

(term hierarchy)
InterPro Domains

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

IPR002144 GPCR, family 2, secretin receptor

IPR050332 G-protein coupled receptor 2

IPR047037 Secretin receptor, 7TM
GlyGen

Q5FWI2 5 sites

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 3

Summaries

All 56

Diseases 1

Gene Ontology 11

Phenotypes 29
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:343601 Aiko M, et al., Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice. Neurosci Res. 2023 Sep 27;

TSS for Sctr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8393	Chr1:119934743-119934758 (+)	41 bp
Tssr8394	Chr1:119934775-119934789 (+)	72 bp
Tssr8395	Chr1:119934802-119934813 (+)	98 bp
Tssr8396	Chr1:119982963-119982966 (+)	48,255 bp
Tssr8397	Chr1:119982979-119982989 (+)	48,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24