Adgrg7 MGI Mouse Gene Detail - MGI:2441732 - adhesion G protein-coupled receptor G7

Symbol

Adgrg7
Name

adhesion G protein-coupled receptor G7
Synonyms

9130020O16Rik, Gpr128

Feature Type

protein coding gene
IDs

MGI:2441732
NCBI Gene: 239853
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:56544972-56616218 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 34.22 cM
Mapping Data

1 experiment

SNPs within 2kb

2135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441732	protein coding gene	Chr16:56544972-56616369 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022891	protein coding gene	Chr16:55859172-55938528 (-)
A/J	MGP_AJ_G0022858	protein coding gene	Chr16:53455251-53542196 (-)
AKR/J	MGP_AKRJ_G0022830	protein coding gene	Chr16:55145494-55226930 (-)
BALB/cJ	MGP_BALBcJ_G0022858	protein coding gene	Chr16:53559892-53630194 (-)
C3H/HeJ	MGP_C3HHeJ_G0022621	protein coding gene	Chr16:55338259-55418838 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023306	protein coding gene	Chr16:57447581-57515239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020817	protein coding gene	Chr16:53136641-53202277 (-)
CAST/EiJ	MGP_CASTEiJ_G0022148	protein coding gene	Chr16:55729617-55808585 (-)
CBA/J	MGP_CBAJ_G0022594	protein coding gene	Chr16:59737795-59817099 (-)
DBA/2J	MGP_DBA2J_G0022726	protein coding gene	Chr16:53216710-53285248 (-)
FVB/NJ	MGP_FVBNJ_G0022701	protein coding gene	Chr16:52981511-53050741 (-)
LP/J	MGP_LPJ_G0022793	protein coding gene	Chr16:55675071-55757714 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022719	protein coding gene	Chr16:60076495-60156708 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023321	protein coding gene	Chr16:55322625-55394122 (-)
PWK/PhJ	MGP_PWKPhJ_G0021887	protein coding gene	Chr16:53538329-53612035 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021717	protein coding gene	Chr16:55072697-55144221 (-)
WSB/EiJ	MGP_WSBEiJ_G0022192	protein coding gene	Chr16:55343820-55419168 (-)

Human Ortholog

ADGRG7, adhesion G protein-coupled receptor G7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRG7, adhesion G protein-coupled receptor G7
Synonyms

GPR128
Links

HGNC:19241

NCBI Gene ID: 84873

neXtProt AC: NX_Q96K78

UniProt: Q96K78
Chr Location

3q12.2; chr3:100609601-100695479 (+) GRCh38

MGI Vertebrate Homology

Adgrg7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADGRG7
Gene Tree

Adgrg7

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS28225.1

Ensembl

ENSMUSG00000022755 (Evidence)
NCBI Gene

239853

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022755	Ensembl Gene Model \| MGI Sequence Detail	71247	C57BL/6J	± kb
transcript	ENSMUST00000023437	Ensembl \| MGI Sequence Detail	2698	Not Applicable
polypeptide	ENSMUSP00000023437	Ensembl \| MGI Sequence Detail	785	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029515 adhesion G-protein coupled receptor G7

(term hierarchy)
InterPro Domains

IPR053066 Adhesion G-protein coupled receptor G7

IPR046338 GAIN domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif

IPR047938 Orphan adhesion receptor GPR128, 7TM domain
GlyGen

Q8BM96 12 sites

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adgrg7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141562	Chr16:56616186-56616262 (-)	-6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24