Gpr82 MGI Mouse Gene Detail - MGI:2441734 - G protein-coupled receptor 82

Symbol

Gpr82
Name

G protein-coupled receptor 82

Feature Type

protein coding gene
IDs

MGI:2441734
NCBI Gene: 319200
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:13527602-13533672 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 8.59 cM
Mapping Data

1 experiment

SNPs within 2kb

190 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441734	protein coding gene	ChrX:13512373-13533672 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035575	protein coding gene	ChrX:8523499-8531001 (+)
A/J	MGP_AJ_G0035553	protein coding gene	ChrX:8615012-8620913 (+)
AKR/J	MGP_AKRJ_G0035485	protein coding gene	ChrX:8896876-8902836 (+)
BALB/cJ	MGP_BALBcJ_G0035546	protein coding gene	ChrX:8465154-8475160 (+)
C3H/HeJ	MGP_C3HHeJ_G0035262	protein coding gene	ChrX:8625107-8631187 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036075	protein coding gene	ChrX:8736613-8743212 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032945	protein coding gene	ChrX:7502585-7508271 (+)
CAST/EiJ	MGP_CASTEiJ_G0034554	protein coding gene	ChrX:8374088-8380741 (+)
CBA/J	MGP_CBAJ_G0035231	protein coding gene	ChrX:9175110-9181127 (+)
DBA/2J	MGP_DBA2J_G0035384	protein coding gene	ChrX:8443554-8449924 (+)
FVB/NJ	MGP_FVBNJ_G0035331	protein coding gene	ChrX:8278882-8284790 (+)
LP/J	MGP_LPJ_G0035466	protein coding gene	ChrX:8698361-8705421 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035374	protein coding gene	ChrX:9086817-9094193 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036087	protein coding gene	ChrX:8439357-8446008 (+)
PWK/PhJ	MGP_PWKPhJ_G0034255	protein coding gene	ChrX:7930703-7937165 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034096	protein coding gene	ChrX:8537995-8546392 (+)
WSB/EiJ	MGP_WSBEiJ_G0034690	protein coding gene	ChrX:8475786-8483049 (+)

Human Ortholog

GPR82, G protein-coupled receptor 82

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR82, G protein-coupled receptor 82
Links

HGNC:4533

NCBI Gene ID: 27197

neXtProt AC: NX_Q96P67

UniProt: Q96P67
Chr Location

Xp11.4; chrX:41724181-41730130 (+) GRCh38

MGI Vertebrate Homology

Gpr82 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR82
Gene Tree

Gpr82

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced body weight and body fat content, lower food intake, decreased serum triacylglyceride levels, and improved glucose tolerance. Mice homozygous for another allele display a normal phenotype.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

49
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

6
UniProt

1
CCDS

CCDS30029.1

Ensembl

ENSMUSG00000047678 (Evidence)
NCBI Gene

319200

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047678	Ensembl Gene Model \| MGI Sequence Detail	6071	C57BL/6J	± kb
transcript	ENSMUST00000053659	Ensembl \| MGI Sequence Detail	2497	Not Applicable
polypeptide	ENSMUSP00000062535	Ensembl \| MGI Sequence Detail	328	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001538 probable G-protein coupled receptor 82

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR042804 Probable G-protein coupled receptor 82
GlyGen

Q8BZR0 2 sites

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All nucleic 6

cDNA 4

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 18

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 3
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:301613 Engel KM, et al., Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82. PLoS One. 2011;6(12):e29400

TSS for Gpr82:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160606	ChrX:13527570-13527582 (+)	-26 bp
Tssr160607	ChrX:13527593-13527605 (+)	-3 bp
Tssr160608	ChrX:13528570-13528582 (+)	974 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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