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Rapgef3 Gene Detail
Summary
  • Symbol
    Rapgef3
  • Name
    Rap guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    2310016P22Rik, 9330170P05Rik, Epac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441741
    NCBI Gene: 223864
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97642651-97665853 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 53.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    683 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441741
 protein coding gene Chr15:97637886-97666300 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022278
 protein coding gene Chr15:99413462-99437538 (-)
A/J MGP_AJ_G0022237
 protein coding gene Chr15:95481542-95506517 (-)
AKR/J MGP_AKRJ_G0022212
 protein coding gene Chr15:98361170-98385679 (-)
BALB/cJ MGP_BALBcJ_G0022243
 protein coding gene Chr15:95708892-95731809 (-)
C3H/HeJ MGP_C3HHeJ_G0022013
 protein coding gene Chr15:98440112-98467780 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022688
 protein coding gene Chr15:103089182-103112484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020214
 protein coding gene Chr15:91430170-91453538 (-)
CAST/EiJ MGP_CASTEiJ_G0021535
 protein coding gene Chr15:99315000-99337847 (-)
CBA/J MGP_CBAJ_G0021980
 protein coding gene Chr15:106545887-106573792 (-)
DBA/2J MGP_DBA2J_G0022107
 protein coding gene Chr15:94934444-94957839 (-)
FVB/NJ MGP_FVBNJ_G0022086
 protein coding gene Chr15:93920845-93946462 (-)
LP/J MGP_LPJ_G0022178
 protein coding gene Chr15:99521132-99545599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022106
 protein coding gene Chr15:110665204-110690725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022703
 protein coding gene Chr15:98514662-98538955 (-)
PWK/PhJ MGP_PWKPhJ_G0021276
 protein coding gene Chr15:95031582-95055067 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021110
 protein coding gene Chr15:98286268-98309772 (-)
WSB/EiJ MGP_WSBEiJ_G0021584
 protein coding gene Chr15:99033410-99059441 (-)



Homology
more
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
  • Synonyms
    bcm910, CAMP-GEFI, EPAC, EPAC1, HSU79275
  • Links
    NCBI Gene ID: 10411
    neXtProt AC: NX_O95398
    UniProt: O95398

  • Chr Location
    12q13.11; chr12:47734363-47771040 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased induced neuron apoptosis. Mice homozygous for a different allele exhibit impaired glucose homeostasis with decreased insulin secretion, increased susceptibility to diet-induced obesity and streptozotocin-induced insulitis and hyperglycemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    17
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022469 Ensembl Gene Model | MGI Sequence Detail 23203 C57BL/6J ±  kb
    transcript ENSMUST00000126854 Ensembl | MGI Sequence Detail 4005 Not Applicable  
    polypeptide ENSMUSP00000116426 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000013728 Rap guanine nucleotide exchange factor 3
      (term hierarchy)
    • InterPro Domains
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR000591 DEP domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR014710 RmlC-like jelly roll fold
      IPR029071 Ubiquitin-like domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917354
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 80
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:340535 Yang W, et al., Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis. Invest Ophthalmol Vis Sci. 2023 Aug 1;64(11):34
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory