Agbl5 MGI Mouse Gene Detail - MGI:2441745 - ATP/GTP binding protein-like 5

Symbol

Agbl5
Name

ATP/GTP binding protein-like 5
Synonyms

9430057O19Rik, Ccp5

Feature Type

protein coding gene
IDs

MGI:2441745
NCBI Gene: 231093
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:31046038-31064309 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.90 cM
Mapping Data

2 experiments

SNPs within 2kb

407 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441745	protein coding gene	Chr5:31045321-31064309 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029398	protein coding gene	Chr5:28846486-28865721 (+)
A/J	MGP_AJ_G0029364	protein coding gene	Chr5:27910669-27928945 (+)
AKR/J	MGP_AKRJ_G0029315	protein coding gene	Chr5:29062210-29080433 (+)
BALB/cJ	MGP_BALBcJ_G0029375	protein coding gene	Chr5:28432146-28450288 (+)
C3H/HeJ	MGP_C3HHeJ_G0029096	protein coding gene	Chr5:29054532-29078455 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029828	protein coding gene	Chr5:30622623-30643546 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027066	protein coding gene	Chr5:25388085-25406432 (+)
CAST/EiJ	MGP_CASTEiJ_G0028507	protein coding gene	Chr5:28153157-28171973 (+)
CBA/J	MGP_CBAJ_G0029064	protein coding gene	Chr5:31199089-31217336 (+)
DBA/2J	MGP_DBA2J_G0029213	protein coding gene	Chr5:28092486-28110767 (+)
FVB/NJ	MGP_FVBNJ_G0029171	protein coding gene	Chr5:27504427-27524466 (+)
LP/J	MGP_LPJ_G0029298	protein coding gene	Chr5:29311247-29329611 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029200	protein coding gene	Chr5:32090011-32110128 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029862	protein coding gene	Chr5:28561607-28580402 (+)
PWK/PhJ	MGP_PWKPhJ_G0028231	protein coding gene	Chr5:27209162-27228460 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028061	protein coding gene	Chr5:27931862-27953239 (+)
WSB/EiJ	MGP_WSBEiJ_G0028587	protein coding gene	Chr5:28627470-28645641 (+)

Human Ortholog

AGBL5, AGBL carboxypeptidase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGBL5, AGBL carboxypeptidase 5
Synonyms

CCP5, RP75
Links

HGNC:26147

NCBI Gene ID: 60509

neXtProt AC: NX_Q8NDL9

UniProt: Q8NDL9
Chr Location

2p23.3; chr2:27042364-27070622 (+) GRCh38

MGI Vertebrate Homology

Agbl5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGBL5
Gene Tree

Agbl5

Diseases

1 with human AGBL5 associations

				Human Disease	Mouse Models
				retinitis pigmentosa 75 IDs retinitis pigmentosa 75 DOID:0110361 ICD10CM:H35.5 OMIM:617023

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

26 phenotypes from 3 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

2
Spontaneous

1
Targeted

4
Genomic Mutations

5 involving Agbl5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a knock-out allele show increased susceptibility to infection with DNA viruses. Homozygotes for a different knock-out allele show defects in multiple steps of spermatogenesis leading to manchette malformation, supernumerary centrioles, defective sperm axonemes, and male infertility.

less

All GO Annotations

28
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agbl5

ZFIN agbl5

less

All Sequences

128
RefSeq

58
UniProt

5
CCDS

CCDS19165.1, CCDS39048.1, CCDS80242.1, CCDS89898.1

Ensembl

ENSMUSG00000029165 (Evidence)
NCBI Gene

231093

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029165	Ensembl Gene Model \| MGI Sequence Detail	18272	C57BL/6J	± kb
transcript	ENSMUST00000201168	Ensembl \| MGI Sequence Detail	3199	Not Applicable
polypeptide	ENSMUSP00000143808	Ensembl \| MGI Sequence Detail	886	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000003827 cytosolic carboxypeptidase-like protein 5

(term hierarchy)
EC

3.4.17.-, 3.4.17.24
InterPro Domains

IPR050821 Cytosolic carboxypeptidase

IPR034286 Cytosolic carboxypeptidase-like protein 5 catalytic domain

IPR040626 Cytosolic carboxypeptidase, N-terminal

IPR000834 Peptidase M14, carboxypeptidase A

less

All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

Summaries

All 62

Developmental Gene Expression 2

Diseases 1

Gene Ontology 12

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:350283 Aljammal R, et al., Excessive tubulin glutamylation leads to progressive cone-rod dystrophy and loss of outer segment integrity. Hum Mol Genet. 2024 Apr 18;33(9):802-817

TSS for Agbl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45635	Chr5:31046271-31046341 (+)	268 bp
Tssr45636	Chr5:31046495-31046536 (+)	478 bp
Tssr45637	Chr5:31046640-31046664 (+)	614 bp
Tssr45638	Chr5:31046672-31046750 (+)	673 bp
Tssr45639	Chr5:31046757-31046769 (+)	725 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24