Washc4 MGI Mouse Gene Detail - MGI:2441787

Symbol

Washc4
Name

WASH complex subunit 4
Synonyms

A230046K03Rik, mKIAA1033

Feature Type

protein coding gene
IDs

MGI:2441787
NCBI Gene: 319277
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:83379616-83432337 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.29 cM
Mapping Data

2 experiments

SNPs within 2kb

1111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441787	protein coding gene	Chr10:83379073-83432350 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017587	protein coding gene	Chr10:84354809-84407119 (+)
A/J	MGP_AJ_G0017567	protein coding gene	Chr10:81504445-81557519 (+)
AKR/J	MGP_AKRJ_G0017526	protein coding gene	Chr10:83757765-83809958 (+)
BALB/cJ	MGP_BALBcJ_G0017530	protein coding gene	Chr10:81755529-81811220 (+)
C3H/HeJ	MGP_C3HHeJ_G0017352	protein coding gene	Chr10:83852200-83906238 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017987	protein coding gene	Chr10:87258385-87314572 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015671	protein coding gene	Chr10:77203046-77255040 (+)
CAST/EiJ	MGP_CASTEiJ_G0016919	protein coding gene	Chr10:83726672-83782174 (+)
CBA/J	MGP_CBAJ_G0017322	protein coding gene	Chr10:90878111-90936226 (+)
DBA/2J	MGP_DBA2J_G0017428	protein coding gene	Chr10:80656401-80708936 (+)
FVB/NJ	MGP_FVBNJ_G0017422	protein coding gene	Chr10:79894741-79947688 (+)
LP/J	MGP_LPJ_G0017500	protein coding gene	Chr10:84997068-85052284 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017450	protein coding gene	Chr10:92537623-92595031 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018024	protein coding gene	Chr10:83694143-83746882 (+)
PWK/PhJ	MGP_PWKPhJ_G0016700	protein coding gene	Chr10:80524404-80577422 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016490	protein coding gene	Chr10:82299490-82353054 (+)
WSB/EiJ	MGP_WSBEiJ_G0016978	protein coding gene	Chr10:83708877-83763378 (+)

Human Ortholog

WASHC4, WASH complex subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WASHC4, WASH complex subunit 4
Synonyms

KIAA1033, MRT43, SWIP
Links

HGNC:29174

NCBI Gene ID: 23325

neXtProt AC: NX_Q2M389

UniProt: Q2M389
Chr Location

12q23.3; chr12:105107324-105169130 (+) GRCh38

MGI Vertebrate Homology

Washc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WASHC4
Gene Tree

Washc4

Diseases

1 with Washc4 mouse models; 1 with human WASHC4 associations

Human Disease

Mouse Models

Wiskott-Aldrich syndrome

IDs

View 1 model

autosomal recessive intellectual developmental disorder 43

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Targeted

2
Genomic Mutations

1 involving Washc4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. Homozygous p.P1019R mutation causes endo-lysosomal disruption, leading to accumulation of neurodegenerative markers and progressive cognitive deficits and motor impairments.

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All GO Annotations

26
GO References

11

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

7
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase washc4

ZFIN washc4

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All Sequences

62
RefSeq

15
UniProt

2
CCDS

CCDS36015.1

Ensembl

ENSMUSG00000034560 (Evidence)
NCBI Gene

319277

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034560	Ensembl Gene Model \| MGI Sequence Detail	52722	C57BL/6J	± kb
transcript	ENSMUST00000038388	Ensembl \| MGI Sequence Detail	5858	Not Applicable
polypeptide	ENSMUSP00000039322	Ensembl \| MGI Sequence Detail	1173	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060149 WASH complex subunit 4

(term hierarchy)
InterPro Domains

IPR028191 WASH complex subunit 4, N-terminal

IPR027307 WASH complex subunit 7

IPR028282 WASH complex subunit 7, central domain

IPR028283 WASH complex subunit 7, C-terminal
GlyGen

Q3UMB9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 6

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MGI:2143496

Summaries

All 48

Developmental Gene Expression 2

Diseases 1

Gene Ontology 11

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Washc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94875	Chr10:83379805-83379871 (+)	222 bp
Tssr94876	Chr10:83379876-83379887 (+)	266 bp
Tssr94877	Chr10:83398103-83398119 (+)	18,495 bp
Tssr94878	Chr10:83400912-83400928 (+)	21,304 bp
Tssr94879	Chr10:83426844-83426864 (+)	47,238 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24