Cdc42bpa MGI Mouse Gene Detail - MGI:2441841 - CDC42 binding protein kinase alpha

Sequence Map

Chr1:179788037-179993168 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441841	protein coding gene	Chr1:179787058-179993171 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016865	protein coding gene	Chr1:186364044-186580261 (+)
A/J	MGP_AJ_G0016844	protein coding gene	Chr1:178839538-179042068 (+)
AKR/J	MGP_AKRJ_G0016810	protein coding gene	Chr1:184149127-184364581 (+)
BALB/cJ	MGP_BALBcJ_G0016802	protein coding gene	Chr1:179459942-179664707 (+)
C3H/HeJ	MGP_C3HHeJ_G0016627	protein coding gene	Chr1:184916685-185126259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017265	protein coding gene	Chr1:192386542-192603400 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014973	protein coding gene	Chr1:169817495-170019201 (+)
CAST/EiJ	MGP_CASTEiJ_G0016208	protein coding gene	Chr1:184217519-184442696 (+)
CBA/J	MGP_CBAJ_G0016601	protein coding gene	Chr1:199541938-199752498 (+)
DBA/2J	MGP_DBA2J_G0016707	protein coding gene	Chr1:177676627-177878784 (+)
FVB/NJ	MGP_FVBNJ_G0016703	protein coding gene	Chr1:175769073-175971358 (+)
LP/J	MGP_LPJ_G0016781	protein coding gene	Chr1:187629406-187843152 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016734	protein coding gene	Chr1:206697779-206961150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017302	protein coding gene	Chr1:183907727-184137503 (+)
PWK/PhJ	MGP_PWKPhJ_G0015996	protein coding gene	Chr1:176756293-176962272 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015772	protein coding gene	Chr1:182842526-183063694 (+)
WSB/EiJ	MGP_WSBEiJ_G0016271	protein coding gene	Chr1:184116278-184335928 (+)

Vertebrate Orthology Source

Alliance of Genome Resources

MGI Vertebrate Homology

Cdc42bpa stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CDC42BPA
Gene Tree

Cdc42bpa

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

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			Length	Strain/Species	Flank
genomic	ENSMUSG00000026490	Ensembl Gene Model \| MGI Sequence Detail	205132	C57BL/6J	± kb
transcript	ENSMUST00000212756	Ensembl \| MGI Sequence Detail	5247	Not Applicable
polypeptide	ENSMUSP00000148469	Ensembl \| MGI Sequence Detail	1748	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000005205 serine/threonine-protein kinase MRCK alpha

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR001180 Citron homology (CNH) domain

IPR000095 CRIB domain

IPR020454 Diacylglycerol/phorbol-ester binding

IPR031597 KELK-motif containing domain

IPR014930 Myotonic dystrophy protein kinase, coiled coil

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050839 Rho-associated Serine/Threonine Kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR026611 Serine/threonine-protein kinase MRCK alpha, catalytic domain
GlyGen

Q3UU96 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8

TSS for Cdc42bpa:

(View these features in JBrowse)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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