Arhgef11 MGI Mouse Gene Detail - MGI:2441869 - Rho guanine nucleotide exchange factor 11

Symbol

Arhgef11
Name

Rho guanine nucleotide exchange factor 11
Synonyms

PDZ-RhoGEF, Prg

Feature Type

protein coding gene
IDs

MGI:2441869
NCBI Gene: 213498
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:87524866-87645341 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.22 cM
Mapping Data

1 experiment

SNPs within 2kb

2765 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441869	protein coding gene	Chr3:87524855-87645346 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027365	protein coding gene	Chr3:87728209-87854136 (+)
A/J	MGP_AJ_G0027329	protein coding gene	Chr3:84758636-84878935 (+)
AKR/J	MGP_AKRJ_G0027295	protein coding gene	Chr3:86798097-86932401 (+)
BALB/cJ	MGP_BALBcJ_G0027338	protein coding gene	Chr3:84846742-84974605 (+)
C3H/HeJ	MGP_C3HHeJ_G0027081	protein coding gene	Chr3:87100293-87227798 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027784	protein coding gene	Chr3:90957613-91085242 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025137	protein coding gene	Chr3:80371531-80498749 (+)
CAST/EiJ	MGP_CASTEiJ_G0026528	protein coding gene	Chr3:87316242-87446106 (+)
CBA/J	MGP_CBAJ_G0027056	protein coding gene	Chr3:94026863-94164351 (+)
DBA/2J	MGP_DBA2J_G0027192	protein coding gene	Chr3:84241220-84362240 (+)
FVB/NJ	MGP_FVBNJ_G0027161	protein coding gene	Chr3:82519781-82641169 (+)
LP/J	MGP_LPJ_G0027300	protein coding gene	Chr3:88687723-88821207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027180	protein coding gene	Chr3:100293408-100433785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027842	protein coding gene	Chr3:86572099-86702132 (+)
PWK/PhJ	MGP_PWKPhJ_G0026261	protein coding gene	Chr3:84042233-84164579 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026078	protein coding gene	Chr3:85764006-85890053 (+)
WSB/EiJ	MGP_WSBEiJ_G0026607	protein coding gene	Chr3:86939707-87068246 (+)

Human Ortholog

ARHGEF11, Rho guanine nucleotide exchange factor 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF11, Rho guanine nucleotide exchange factor 11
Synonyms

GTRAP48, PDZ-RHOGEF
Links

HGNC:14580

NCBI Gene ID: 9826

neXtProt AC: NX_O15085

UniProt: O15085
Chr Location

1q23.1; chr1:156934840-157046903 (-) GRCh38

MGI Vertebrate Homology

Arhgef11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGEF11
Gene Tree

Arhgef11

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotypes from multigenic genotypes
2 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

25
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Arhgef11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit no obvious phenotype.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

27
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGEF11

Xenbase arhgef11

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All Sequences

100
RefSeq

49
UniProt

8
CCDS

CCDS38472.1

Ensembl

ENSMUSG00000041977 (Evidence)
NCBI Gene

213498

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041977	Ensembl Gene Model \| MGI Sequence Detail	120476	C57BL/6J	± kb
transcript	ENSMUST00000039476	Ensembl \| MGI Sequence Detail	6776	Not Applicable
polypeptide	ENSMUSP00000039900	Ensembl \| MGI Sequence Detail	1552	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR041020 ARHGEF1-like, PH domain

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR015212 Regulator of G protein signalling-like domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR037803 Rho guanine nucleotide exchange factor 11, PH domain

IPR037889 Rho guanine nucleotide exchange factor 11, RGS domain
GlyGen

Q68FM7 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 7

Diseases 1

Gene Ontology 4

Phenotypes 19
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29826	Chr3:87524848-87524920 (+)	18 bp
Tssr29827	Chr3:87528224-87528229 (+)	3,361 bp
Tssr29828	Chr3:87536794-87536803 (+)	11,933 bp
Tssr29829	Chr3:87558267-87558270 (+)	33,403 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24