Mrgpre MGI Mouse Gene Detail - MGI:2441884

Symbol

Mrgpre
Name

MAS-related GPR, member E
Synonyms

C130069N09Rik, MrgE

Feature Type

protein coding gene
IDs

MGI:2441884
NCBI Gene: 244238
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:143332100-143338237 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.31 cM
Mapping Data

1 experiment

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441884	protein coding gene	Chr7:143332100-143338237 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033282	protein coding gene	Chr7:149107208-149113342 (-)
A/J	MGP_AJ_G0033265	protein coding gene	Chr7:144775484-144781547 (-)
AKR/J	MGP_AKRJ_G0033196	protein coding gene	Chr7:148851239-148860725 (-)
BALB/cJ	MGP_BALBcJ_G0033265	protein coding gene	Chr7:144570657-144576612 (-)
C3H/HeJ	MGP_C3HHeJ_G0032979	protein coding gene	Chr7:148612134-148618541 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033775	protein coding gene	Chr7:154505104-154511166 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030748	protein coding gene	Chr7:145946144-145952167 (-)
CAST/EiJ	MGP_CASTEiJ_G0032302	protein coding gene	Chr7:140928681-140934731 (-)
CBA/J	MGP_CBAJ_G0032952	protein coding gene	Chr7:159742981-159749136 (-)
DBA/2J	MGP_DBA2J_G0033106	protein coding gene	Chr7:142758376-142764427 (-)
FVB/NJ	MGP_FVBNJ_G0033054	protein coding gene	Chr7:142700937-142707104 (-)
LP/J	MGP_LPJ_G0033198	protein coding gene	Chr7:150646706-150652825 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033088	protein coding gene	Chr7:160352646-160359556 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033793	protein coding gene	Chr7:147808111-147814212 (-)
PWK/PhJ	MGP_PWKPhJ_G0032012	protein coding gene	Chr7:136064977-136071029 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031856	protein coding gene	Chr7:134612556-134618624 (-)
WSB/EiJ	MGP_WSBEiJ_G0032415	protein coding gene	Chr7:148806567-148813192 (-)

Human Ortholog

MRGPRE, MAS related GPR family member E

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRGPRE, MAS related GPR family member E
Synonyms

GPR167, MGRF, MRGE
Links

HGNC:30694

NCBI Gene ID: 116534

neXtProt AC: NX_Q86SM8

UniProt: Q86SM8
Chr Location

11p15.4; chr11:3225030-3232417 (-) GRCh38

MGI Vertebrate Homology

Mrgpre stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MRGPRE
Gene Tree

Mrgpre

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit alterations in the development but not maintenance of allodynia.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

32
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

4
UniProt

2
CCDS

CCDS22046.1

Ensembl

ENSMUSG00000048965 (Evidence)
NCBI Gene

244238

			Length	Strain/Species	Flank
genomic	244238	NCBI Gene Model \| MGI Sequence Detail	6138	C57BL/6J	± kb
transcript	NM_175534	RefSeq \| MGI Sequence Detail	3777	C57BL/6
polypeptide	Q91ZB7	UniProt \| EBI \| MGI Sequence Detail	310	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001603 Mas-related G-protein coupled receptor E

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR026230 Mas-related G protein-coupled receptor E

IPR026234 Mas-related G protein-coupled receptor family
GlyGen

Q91ZB7 2 sites

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All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 6
Earliest

J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrgpre:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75985	Chr7:143338012-143338063 (-)	199 bp
Tssr75984	Chr7:143334249-143334252 (-)	3,986 bp
Tssr75983	Chr7:143334160-143334167 (-)	4,073 bp
Tssr75982	Chr7:143334028-143334039 (-)	4,203 bp
Tssr75981	Chr7:143333972-143333994 (-)	4,254 bp
Tssr75980	Chr7:143333959-143333970 (-)	4,272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24