Gpr21 MGI Mouse Gene Detail - MGI:2441890 - G protein-coupled receptor 21

Symbol

Gpr21
Name

G protein-coupled receptor 21
Synonyms

C230004C13Rik

Feature Type

protein coding gene
IDs

MGI:2441890
NCBI Gene: 338346
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:37406638-37409293 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 24.19 cM
Mapping Data

1 experiment

SNPs within 2kb

92 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441890	protein coding gene	Chr2:37406344-37410615 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025698	protein coding gene	Chr2:36216591-36220862 (+)
A/J	MGP_AJ_G0025675	protein coding gene	Chr2:34734800-34739071 (+)
AKR/J	MGP_AKRJ_G0025645	protein coding gene	Chr2:35891604-35895875 (+)
BALB/cJ	MGP_BALBcJ_G0025670	protein coding gene	Chr2:34796915-34801186 (+)
C3H/HeJ	MGP_C3HHeJ_G0025431	protein coding gene	Chr2:35808418-35812689 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026116	protein coding gene	Chr2:37252205-37256476 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023521	protein coding gene	Chr2:33407938-33412316 (+)
CAST/EiJ	MGP_CASTEiJ_G0024894	protein coding gene	Chr2:35718466-35722679 (+)
CBA/J	MGP_CBAJ_G0025410	protein coding gene	Chr2:38650954-38655225 (+)
DBA/2J	MGP_DBA2J_G0025542	protein coding gene	Chr2:34478584-34482855 (+)
FVB/NJ	MGP_FVBNJ_G0025504	protein coding gene	Chr2:34359428-34363699 (+)
LP/J	MGP_LPJ_G0025629	protein coding gene	Chr2:36105492-36109763 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025535	protein coding gene	Chr2:38247805-38252076 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026174	protein coding gene	Chr2:35769723-35773994 (+)
PWK/PhJ	MGP_PWKPhJ_G0024636	protein coding gene	Chr2:34374322-34378689 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024441	protein coding gene	Chr2:35881794-35886267 (+)
WSB/EiJ	MGP_WSBEiJ_G0024962	protein coding gene	Chr2:35954092-35958363 (+)

Human Ortholog

GPR21, G protein-coupled receptor 21

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR21, G protein-coupled receptor 21
Links

HGNC:4476

NCBI Gene ID: 2844

neXtProt AC: NX_Q99679

UniProt: Q99679
Chr Location

9q33.2; chr9:123033667-123049103 (+) GRCh38

MGI Vertebrate Homology

Gpr21 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR21
Gene Tree

Gpr21

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit improved glucose tolerance, insulin response and resistance to diet-induced obesity.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

68
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS16004.1

Ensembl

ENSMUSG00000053164 (Evidence)
NCBI Gene

338346

			Length	Strain/Species	Flank
genomic	338346	NCBI Gene Model \| MGI Sequence Detail	2656	C57BL/6J	± kb
transcript	NM_177383	RefSeq \| MGI Sequence Detail	2297	C57BL/6
polypeptide	Q8BX79	UniProt \| EBI \| MGI Sequence Detail	349	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030467 probable G-protein coupled receptor 21

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR050569 Trace Amine-Associated Receptor
GlyGen

Q8BX79 2 sites

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All nucleic 14

cDNA 14

Microarray probesets 1

Summaries

All 26

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Gpr21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17527	Chr2:37406604-37406618 (+)	-27 bp
Tssr17528	Chr2:37406630-37406646 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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