Ppp2r3a MGI Mouse Gene Detail - MGI:2442104 - protein phosphatase 2, regulatory subunit B'', alpha

Symbol

Ppp2r3a
Name

protein phosphatase 2, regulatory subunit B'', alpha
Synonyms

3222402P14Rik, C530025M11Rik

Feature Type

protein coding gene
IDs

MGI:2442104
NCBI Gene: 235542
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:100982283-101128994 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 53.19 cM
Mapping Data

1 experiment

SNPs within 2kb

3252 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442104	protein coding gene	Chr9:100982188-101129031 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035182	protein coding gene	Chr9:102587562-102739826 (-)
A/J	MGP_AJ_G0035163	protein coding gene	Chr9:98952749-99094838 (-)
AKR/J	MGP_AKRJ_G0035095	protein coding gene	Chr9:101359195-101503628 (-)
BALB/cJ	MGP_BALBcJ_G0035156	protein coding gene	Chr9:98640048-98784655 (-)
C3H/HeJ	MGP_C3HHeJ_G0034866	protein coding gene	Chr9:101794980-101940183 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035676	protein coding gene	Chr9:105517773-105670677 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032575	protein coding gene	Chr9:96586645-96719787 (-)
CAST/EiJ	MGP_CASTEiJ_G0034177	protein coding gene	Chr9:101598784-101744821 (-)
CBA/J	MGP_CBAJ_G0034834	protein coding gene	Chr9:109186806-109338063 (-)
DBA/2J	MGP_DBA2J_G0034996	protein coding gene	Chr9:98437934-98581462 (-)
FVB/NJ	MGP_FVBNJ_G0034944	protein coding gene	Chr9:97242513-97385639 (-)
LP/J	MGP_LPJ_G0035072	protein coding gene	Chr9:102805087-102958649 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034983	protein coding gene	Chr9:111066594-111175738 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035698	protein coding gene	Chr9:101632201-101777498 (-)
PWK/PhJ	MGP_PWKPhJ_G0033884	protein coding gene	Chr9:98677733-98813548 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033720	protein coding gene	Chr9:101675599-101811776 (-)
WSB/EiJ	MGP_WSBEiJ_G0034297	protein coding gene	Chr9:101508236-101652482 (-)

Human Ortholog

PPP2R3A, protein phosphatase 2 regulatory subunit B''alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP2R3A, protein phosphatase 2 regulatory subunit B''alpha
Synonyms

PPP2R3, PR130, PR72
Links

HGNC:9307

NCBI Gene ID: 5523

neXtProt AC: NX_Q06190

UniProt: Q06190
Chr Location

3q22.2-q22.3; chr3:135965728-136147894 (+) GRCh38

MGI Vertebrate Homology

Ppp2r3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP2R3A
Gene Tree

Ppp2r3a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Ppp2r3a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

18
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ppp2r3a

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All Sequences

72
RefSeq

13
UniProt

7
CCDS

CCDS52899.1, CCDS52900.1

Ensembl

ENSMUSG00000043154 (Evidence)
NCBI Gene

235542

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043154	Ensembl Gene Model \| MGI Sequence Detail	146712	C57BL/6J	± kb
transcript	ENSMUST00000075941	Ensembl \| MGI Sequence Detail	6786	Not Applicable
polypeptide	ENSMUSP00000075327	Ensembl \| MGI Sequence Detail	1150	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013139 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR041534 PP2A regulatory subunit B'', EF-hand domain

IPR048855 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha/beta/delta, EF-hand

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 5

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MGI:2441907

Summaries

All 30

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp2r3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91116	Chr9:101129040-101129051 (-)	-52 bp
Tssr91115	Chr9:101129009-101129038 (-)	-30 bp
Tssr91114	Chr9:101128975-101129001 (-)	6 bp
Tssr91113	Chr9:101128941-101128955 (-)	46 bp
Tssr91112	Chr9:101128669-101128680 (-)	319 bp
Tssr91111	Chr9:101120925-101120940 (-)	8,061 bp
Tssr91110	Chr9:101076280-101076287 (-)	52,710 bp
Tssr91109	Chr9:101076198-101076279 (-)	52,755 bp
Tssr91108	Chr9:101076175-101076196 (-)	52,808 bp
Tssr91107	Chr9:101076139-101076153 (-)	52,848 bp
Tssr91105	Chr9:100997927-100997931 (-)	131,065 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24