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Daglb Gene Detail
Summary
  • Symbol
    Daglb
  • Name
    diacylglycerol lipase, beta
  • Synonyms
    E330036I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442032
    NCBI Gene: 231871
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143450239-143490197 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442032
 protein coding gene Chr5:143450239-143491697 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030332
 protein coding gene Chr5:148792715-148838319 (+)
A/J MGP_AJ_G0030301
 protein coding gene Chr5:142412761-142455148 (+)
AKR/J MGP_AKRJ_G0030233
 protein coding gene Chr5:146866901-146913683 (+)
BALB/cJ MGP_BALBcJ_G0030318
 protein coding gene Chr5:143656948-143698553 (+)
C3H/HeJ MGP_C3HHeJ_G0030029
 protein coding gene Chr5:147688471-147730042 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030763
 protein coding gene Chr5:154234442-154279223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027981
 protein coding gene Chr5:136182357-136223933 (+)
CAST/EiJ MGP_CASTEiJ_G0029434
 protein coding gene Chr5:147184329-147227385 (+)
CBA/J MGP_CBAJ_G0029999
 protein coding gene Chr5:160591307-160638824 (+)
DBA/2J MGP_DBA2J_G0030149
 protein coding gene Chr5:142176836-142218153 (+)
FVB/NJ MGP_FVBNJ_G0030104
 protein coding gene Chr5:141386678-141428969 (+)
LP/J MGP_LPJ_G0030235
 protein coding gene Chr5:149393845-149439504 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030135
 protein coding gene Chr5:162979154-163022100 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030803
 protein coding gene Chr5:146729525-146771566 (+)
PWK/PhJ MGP_PWKPhJ_G0029149
 protein coding gene Chr5:141258891-141302410 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028985
 protein coding gene Chr5:144465639-144506934 (+)
WSB/EiJ MGP_WSBEiJ_G0029507
 protein coding gene Chr5:147516326-147562699 (+)



Homology
more
  • Human Ortholog
    DAGLB, diacylglycerol lipase beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAGLB, diacylglycerol lipase beta
  • Synonyms
    DAGLBETA, KCCR13L
  • Links
    NCBI Gene ID: 221955
    neXtProt AC: NX_Q8NCG7
    UniProt: Q8NCG7

  • Chr Location
    7p22.1; chr7:6409126-6484190 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations have a reduction in endocannabinoids in the brain and a decrease in adult neuronal proliferation in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    8
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231871 NCBI Gene Model | MGI Sequence Detail 39959 C57BL/6J ±  kb
    transcript NM_144915 RefSeq | MGI Sequence Detail 3257 C57BL/6  
    polypeptide Q91WC9 UniProt | EBI | MGI Sequence Detail 669 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:338571 Buzzi B, et al., Differential roles of diacylglycerol lipase (DAGL) enzymes in nicotine withdrawal. Brain Res. 2023 Jul 11;1817:148483
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory